The role of Wnt/β-catenin signaling pathway in blood leukemias
Journal Title: Khoon - Year 2018, Vol 15, Issue 2
Abstract
The role of Wnt/β-catenin signaling pathway in blood leukemias Ghari M.1, Fathi E.1, Farahzadi R.2 1Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran 2Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Abstract Background and Objectives Wnt/β-catenin signaling pathway is one of the key cascades regulating development and stability of immune and blood cells, but its precise role is still controversial and is the subject of many studies. With activation of the canonical Wnt/β-catenin signaling pathway, β-catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. The canonical Wnt ⁄ β-catenin signaling pathway is aberrantly activated in cancers, and it has therefore been investigated as a potential therapeutic target for the treatment of cancer. In this article, the significance of the canonical Wnt signaling pathway and its impact on blood leukemias development will be described, and how the change in the Wnt signaling pathway will cause any types of leukemia. Materials and Methods The data of the present article were obtained through the review of many papers published on the effect of Wnt / β-catenin signaling pathway on various types of leukemia. Results The review of various studies has shown that Wnt / β-catenin signaling pathway (canonical and non-canonical) is involved at a specific stage during pathogenesis of all types of hematologic malignancies. Conclusions Since the Wnt/β-catenin signaling pathway plays an important role in the natural hematopoiesis and cellular malignancy in hematopoiesis system, evidently the changes in Wnt/ β-catenin signaling pathway provide therapeutic intervention opportunities, especially because of the significant increased level of Wnt/β-catenin signaling pathway in hematologic malignancies compared to other signaling pathways. Key words: Wnt Signaling Pathway, Leukemia، Chronic Myeloid, Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Chronic Lymphocytic Leukemia Received: 25 Nov 2017 Accepted: 30 Jan 2018 Correspondence: Fathi E., Specialist in Clinical Veterinary Pathology. Associate Professor of Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz. Postal Code: 5166616471, Tabriz, Iran. Tel: (+9841) 13392351; Fax: (+9841) 13357834 E-mail: ez.fathi@tabrizu.ac.ir
Authors and Affiliations
M. Ghari, E. Fathi, R. Farahzadi
Keywords
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