The rs1801260 CLOCK polymorphism, links to depression, insomnia and diurnal preference – preliminary findings from a Romanian sample.
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2009, Vol 1, Issue 2
Abstract
Objective: We investigated the possible effect of the T3111C CLOCK gene polymorphism on depressive disorder, insomnia and diurnal preference. Material and methods: twenty seven subjects, aged 23-71, self-selected from a larger sample of healthy controls and clinically depressed patients were creened for the presence of the aforementioned SNP. Results: We detected a possible association of the T/T allele with depression. Conclusion: No support was found for an involvement in sleep disturbance or circadian preference, but CLOCK may be involved in the pathogenesis of depressive disorders.
Authors and Affiliations
Bogdan Voinescu, Johannes Thome, Remus Orasan
Keywords
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