The Signifcance of Matrix Metalloproteinases in the Immunopathogenesis and Treatment of Multiple Sclerosis

Journal Title: Sultan Qaboos University Medical Journal - Year 2014, Vol 14, Issue 1

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Te major pathological outcomes of the disease are the loss of blood-brain barrier (BBB) integrity and the development of reactive astrogliosis and MS plaque. For the disease to occur, the non-resident cells must enter into the immune-privileged CNS through a breach in the relatively impermeable BBB. It has been demonstrated that matrix metalloproteinases (MMPs) play an important role in the immunopathogenesis of MS, in part through the disruption of the BBB and the recruitment of inflammatory cells into the CNS. Moreover, MMPs can also enhance the cleavage of myelin basic protein (MBP) and the demyelination process. Regarding the growing data on the roles of MMPs and their tissue inhibitors (TIMPs) in the pathogenesis of MS, this review discusses the role of different types of MMPs, including MMP-2, -3, -7, -9, -12 and -25, in the immunopathogenesis and treatment of MS

Authors and Affiliations

Abbas Mirshafey| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Babak Asghari| Antimicrobial Resistance Research Center, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran, Ghasem Ghalamfarsa| Cellular & Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Farhad Jadidi-Niaragh| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Gholamreza Azizi| Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran

Keywords

Related Articles

Clinical Outcomes and Counselling Issues regarding Partial Trisomy of Terminal Xp in a Child with Developmental Delay

Female carriers of balanced translocations involving an X chromosome and an autosome offer genetic counselling challenges. Tis is in view of the number of possible meiotic outcomes, but also due to the impact of X chr...

The Need for New Anti-Hepatitis C Virus Therapeutic Strategies Targeting the cellular micro-ribonucleic acids?

Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efci...

Causes of Stress and Coping Strategies Adopted by Undergraduate Health Professions Students in a University in the United Arab Emirates

Objectives: Tis study aimed to compare causes of stress and coping strategies adopted by a sample of undergraduate health-profession students at the Gulf Medical University, United Arab Emirates. Methods: An anonymous...

The Effect of Change in Posture on Spirometry in Patients with Obstructive Sleep Apnoea Syndrome

Objectives: Obstructive sleep apnoea syndrome (OSAS) is a growing health concern as it is associated with serious comorbidities. OSAS is mainly related to obesity, age, gender and a narrowed upper airway is commonly seen...

Download PDF file
  • EP ID EP14419
  • DOI -
  • Views 337
  • Downloads 9

How To Cite

Abbas Mirshafey, Babak Asghari, Ghasem Ghalamfarsa, Farhad Jadidi-Niaragh, Gholamreza Azizi (2014). The Signifcance of Matrix Metalloproteinases in the Immunopathogenesis and Treatment of Multiple Sclerosis. Sultan Qaboos University Medical Journal, 14(1), 13-25. https://europub.co.uk/articles/-A-14419