The significance of anti-DFS70 antibodies in the diagnosis of autoimmune disorders
Journal Title: Family Medicine & Primary Care Review - Year 2017, Vol 19, Issue 2
Abstract
Background. Anti-DFS70 antibodies are a subgroup of antinuclear antibodies (ANA). They are connected with the dense fine speckled autoantigen of 70 kD, known as the lens epithelium-derived growth factor p75. Objectives. The objective of the review is to present the role of anti-DFS70 antibodies in the diagnosis of autoimmune diseases on the basis of recent publications. Material and methods. The authors searched for articles in the Pubmed database using the key words: anti-DFS70 antibodies, systemic autoimmune rheumatic diseases and autoimmune disorders. Results. Anti-DFS70 antibodies can be detected in eye diseases, atopic diseases, alopecia areata, fibromyalgia, asthma, chronic fatigue syndrome, tumors, Hashimoto’s disease, Graves’ disease, Behcet’s disease, inflammatory bowel diseases, neoplasms and in infectious diseases. These antibodies are sometimes detected in patients with ANA-associated rheumatic diseases (AARD ). Up to 20% of serum samples from healthy individuals (HI) are ANA-positive. This is probably due to the presence of monospecific anti-DFS70 antibodies. Monospecific anti-DFS70 antibodies are not associated with AARD , but mixed anti-DFS70 can be found in AARD . Conclusions. Family physicians usually do not order ANA, extractable nuclear antigens (ENA) or anti-DFS70 antibodies, but they should be aware that anti-DFS70 antibodies are biomarkers that can discriminate AARD from non-AARD , save patients from unnecessary, potentially toxic treatment and save finances typically spent on retesting and visits to specialists
Authors and Affiliations
Barbara Nieradko-Iwanicka, Joanna Pekar, Justyna Skolarczyk
Keywords
Related Articles
- EP ID EP232081
- DOI -
- Views 68
- Downloads 0
Czynniki społeczno-demograficzne wpływające na jakość życia pacjentów z astmą i POChP
Wstęp. Choroby przewlekłe układu oddechowego ze względu na swój charakter oraz zróżnicowane objawy wpływają znacząco na codzienne funkcjonowanie chorego. Zarówno astma, jak i POC hP, należące do tej grupy chorób przyczyn...
Analiza efektów pielęgnowania i wiedzy pielęgniarek na temat obwodowego dostępu naczyniowego według kryteriów PIVA
Wstęp. Dostęp do linii naczyniowej i terapia dożylna należą do ważnych elementów terapii zarówno w warunkach szpitalnych, jak i środowisku domowym. U większości pacjentów (ponad 80%) wykorzystuje się obwodowy dostęp nacz...
The knowledge of selected cancer prevention methods among Polish outpatients
Background. Most prevalent cancers are, in their majority, not fully preventable. However, early diagnosis dramatically increases the chances for effective treatment and positive prognosis. Unfortunately, patients’ parti...
Impact of demographic factors on usage of stress coping strategies chosen by elderly people
Background. Old age is a particular time in which people experience plenty of changes – both progressive and regressive. Their social and economic position is changing, and human beings are confronted with a lot of diffi...
What do academicians know about periodic health examinations?
disease. Objectives. Evaluation of the level of knowledge, perception and status of action for periodic health examinations of academicians at Cukurova University. Material and methods. Our sample was 392 academicians at...