The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation
Journal Title: Turkish Journal of Obstetrics and Gynecology - Year 2017, Vol 14, Issue 1
Abstract
Objective: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks’ gestation and trisomy 21 and adverse perinatal outcomes. Materials and Methods: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus venosus Doppler (DVD) measurements were obtained throughout the 6-month period from women who underwent amniocentesis procedures due to increased risk for trisomy 21 in terms of first or second trimester screening test results. These women were followed up for enrollment of subsequent data about perinatal outcomes. Results: In 13 of 174 cases, Doppler studies indicated a reversed a-wave in the ductus venosus. Of these fetuses, 3 were diagnosed as having trisomy 21 after amniocentesis, which related to 60% (3 of 5 fetuses) of all fetuses with trisomy 21. The pregnant women with reversed a-wave in DVD also had an increased rate of preeclampsia (15%) and gestational diabetes mellitus (GDM) (23%) in late pregnancy. Conclusion: Reversed a-wave in ductus venosus between 16-20 weeks’ gestation is associated with increased risk of trisomy 21, preeclampsia, and GDM. If further prospective studies confirm its utility, DVD interrogation for trisomy 21 may be extended until 20 weeks’ gestation.
Authors and Affiliations
Gökhan Karakoç, And Yavuz, Serenat Eriş Yalçın, Mehmet Özgür Akkurt, Nuri Danışman
Keywords
Related Articles
- EP ID EP240587
- DOI 10.4274/tjod.61482
- Views 160
- Downloads 0
The impact of different 75 g oral glucose tolerance test target ranges within normal limits on neonatal outcomes: A validation study
Objective: To investigate the impact of different 75 g glucose tolerance test (OGTT) target ranges within normal limits on neonatal outcomes, thus to investigate the validity of 75 g OGTT thresholds. Materials and Metho...
Can we predict severity of intrahepatic cholestasis of pregnancy using inflammatory markers?
Objective: To investigate the association of inflammatory markers with severity of intrahepatic cholestasis of pregnancy (ICP). Materials and Methods: This retrospective case-control study was conducted with 229 pregnant...
Use of a gelatin-thrombin hemostatic matrix in obstetrics and gynecological surgery
Gelatin-thrombin matrix (GTM) is a hemostatic sealant consisting of bovine-derived gelatin matrix and human-derived thrombin, combining both mechanical and active mechanisms to achieve hemostasis. It was approved by the...
Cost-effectiveness of GnRH antagonist implementation on hCG injection day
Objective: To compare the outcomes of antagonist stimulation protocols and to compare the cost effectiveness. Materials and Methods: Between 2011 and December 2017, a total of 354 women who underwent intracytoplasmic spe...
YKL-40 in the diagnosis, prediction of prognosis, and platinum sensitivity in serous epithelial ovarian cancer
Objective: To evaluate the use of YKL-40 in the discrimination between benign and malignant adnexal mass and to determine its prognostic value in assessing residual tumor after primary cytoreduction and platinum sensitiv...