The Significance of Tzanck Smear in Evaluation of Vesiculo Bullous Skin Lesions in Correlation with Clinical Diagnosis - A Cross Sectional Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Cytology is a diagnostic tool used to investigate the characteristics of individual cells. Tzanck smear is a rapid, simple sensitive cytology technique that can be performed with minimal patient discomfort and cost. This study was thus aimed to establish the significance of Tzanck smear in evaluating the vesiculo bullous disorders in correlation with the clinical diagnosis. Material and methods: A cross sectional study was conducted to know the significance of Tzanck smear in evaluation of various vesiculo bullous skin lesions in comparison with clinical diagnosis. Fisher’s exact test was used for statistical analysis. Results: Out of the 70 patients studied, majority had viral infections and auto immune vesiculo bullous disorders. All the patients with viral infection showed multi nucleated giant cells on cytology and all the patients with pemphigus group of disorder revealed plenty of acantholytic cells, along with inflammatory infiltrate. All the bullous pemphigoid patients showed signicant number of eosinophils. There was highly significant correlation between the presence of acantholytic cells, multi nucleate giant cells as well as eosinophils with clinical diagnosis. Conclusion: Although not a substitute for standard histology, Tzanck smear can aid in establishing the clinical diagnosis with ease and rapidity.
Authors and Affiliations
Heera K P, Anoop TV, Ajaya Kumar S, Robins K, Rajiv S
Keywords
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