The Significant Association of the dupA and cagA genes of Helicobacter pylori with Peptic Ulcer
Journal Title: Journal of Human Environment and Health Promotion - Year 2018, Vol 4, Issue 4
Abstract
Background: Helicobacter pylori play a significant etiological role in various digestive diseases. Peptic ulcer is caused by H. pylori, which destroys the duodenum mucus and is often observed in the individuals consuming tobacco, spicy and heavy meals, alcohol, coffee, and tranquilizers. Several studies have indicated that duodenal ulcer promoting genes dupA and cagA are involved in H. pylori etiology. The present study aimed to evaluate the correlation between these genes and peptic ulcer. Methods: In this study, 500 stomach biopsy samples were assessed based on the rapid urease test and polymerase chain reaction (PCR) for H. pylori infection, followed by histological and microscopic examinations. Results: The dupA and cagA genes were subjected to PCR. Although dupA showed no significant correlation with peptic ulcer, the cagA genotype had a significant association with peptic ulcer (P < 0.05). Similar to the dupA gene, blood group was not observed to be correlated with H. pylori infection. Conclusion: According to the results, there are significant correlations between tobacco use (P < 0.05), tranquilizer use (P < 0.05), and meteorism (P < 0.05) with peptic ulcer. In addition, the expression of the cagA and dupA genes was investigated in patients with non-ulcer dyspepsia and peptic ulcer.
Authors and Affiliations
Hamid Reza Zeraatgar Gohardani, Ehsan Moghanloo, Parisa Badameh, Soheila Rezaei, Vahid Babaei, Shahram Teimourian *
Keywords
Related Articles
- EP ID EP559514
- DOI 10.29252/jhehp.4.4.3
- Views 67
- Downloads 0
Isotherm and Kinetic Evaluation of Acid Blue 80 Dye Adsorption on Surfactant modified Bentonite
Background: Dyes are among the most hazardous chemical compounds, which are found in industrial effluents. The removal of dyes before the discharge of wastewater to the environment could reduce these environmental hazard...
Effect of Applying Sunflower Residues as a Green Manure on Increasing Zn Concentration of Two Iranian Wheat Cultivars in a Pb and Cd Polluted Soil
Background: This research was investigated to evaluate effect of applying sunflower residues as a green manure on increasing zinc (Zn) concentration of two Iranian wheat cultivars in a Pb and cadmium (Cd) polluted soil....
Antibacterial Effects of Agicoat Silver Crystalline Nanofibers on Wound Infection Agents
Background: Drug resistance is a major concern in the treatment of burn wounds. The present study aimed to evaluate the effects of silver crystalline nanofibers on the bacteria isolated from burn wounds at Imam Musa Kazi...
The Frequency of Staphylococcus aureus Classical Enterotoxin Genes in Raw Milk Samples in Zanjan, Iran
Background: Staphylococcus aureus is one of the major causes of food poisoning. Since milk is a nutritious source of proteins and vitamins, it could provide the optimal conditions for the growth of several bacterial path...
Multi-Purpose Ergonomic Backpack for High School Students
Background: Musculoskeletal disorders (MSDs) are among the most prevalent pains which could be ignited via material handling. Backpack wearers are among those who may carry heavy loads. Since MSDs mainly originate in sch...