THE SPECTRUM OF BONE MARROW MORPHOLOGICAL FINDINGS AND ITS DIAGNOSTIC ROLE IN EVALUATION OF HAEMATOLOGICAL DISORDERS- A RETROSPECTIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 45
Abstract
BACKGROUND Bone Marrow Aspiration (BMA) is a relatively safe invasive procedure and gives excellent morphological details of marrow cellular composition to assess the haematopoietic activity. The objective of the present study is to evaluate the spectrum of haematological disorders diagnosed on bone marrow aspiration/ biopsies in a referral centre. MATERIALS AND METHODS Design- A retrospective descriptive study, conducted from July 1st 2016 to 30th June 2018. Setting: Referral care centre in Visakhapatnam, Andhra Pradesh. The present study included all the hospitalised patients in the age group of 0 - 85 years requiring a bone marrow examination for various haematological disorders. A total of 120 patients underwent bone marrow examination during the study period. Aspirate smears were made and stained with Leishman stain. Perls’ Prussian blue stain was used for staining iron and Haematoxylin and Eosin stain was used for bone marrow trephine biopsies. Complete clinical history, physical examination and the laboratory investigations of patients who underwent bone marrow aspiration/ biopsy were noted. RESULTS In the current study, Erythroid hyperplasia and reactive marrow were the common findings. Immune Thrombocytopenic Purpura (ITP) is the 2nd most common finding (12.5%). Acute Myeloid Leukaemia (AML) constituted 8.33% and Acute Lymphoblastic Leukaemia (ALL) constituted 6.66% of total cases. Congenital dyserythropoietic anaemia and bone marrow fibrosis were seen in 3 (2.5%) cases each. Haemophagolymphohistiocytosis, Myelodysplastic syndrome and Non-Hodgkin’s Lymphoma were seen in 2 (1.66%) cases each. CONCLUSION Evaluation of bone marrow morphological details in various haematological diseases can help physicians in appropriate management and treatment of cases.
Authors and Affiliations
Satyasri K, Botta Venkata Satya Kartheek, Sweta Sinha
Keywords
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- EP ID EP549328
- DOI 10.14260/jemds/2018/1084
- Views 68
- Downloads 0
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