The spleen morphological changes under the influence of various factors
Journal Title: Вісник Харківського національного університету імені В.Н.Каразіна. Серія "Біологія" - Year 2016, Vol 27, Issue
Abstract
The spleen is an important peripheral organ of the sanguification and immune defense. Morphological changes in the organ occur under the influence of biotic and abiotic factors of the environment, living conditions, anthropogenic loading. Considering the sensitivity of the spleen to the action of various factors, which have been systemized based on literature data, it is appropriate to use its morphological parameters as biomarkers for the method of biological indication. This method allows characterizing integrated environmental impact on the organism, the possibility of extrapolating the reactions to human. The extent and reversibility of changes depend on the nature of the impact factor, dose, duration, age, type of organism. The features of morphological changes of the spleen have been considered at injuries, impact of different types of electromagnetic radiation, chemicals, metals, toxicants, action of extreme factors, at stress, use of pharmacological agents, biologically active agents, immunomodulators, peculiarities of lifestyle and nutrition, infectious diseases. They occur at the macro- and microscopic levels. The most common changes are characterized by an increase or decrease of such indices: the absolute and relative weight of the organ, relative area of white pulp, area of lymphoid nodules, number of cells, relative area of trabecular system, blood vessels. In the spleen adverse changes manifest in violation of the microcirculation, system of synthesis, appearance of atypical cells or particles, inhibition of hematopoiesis etc.
Authors and Affiliations
O. Dunaіevska
Keywords
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