THE STABILITY OF GENERIC MEROPENEM IN TROPICAL COUNTRIES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
Objective: To evaluate the stability of two brands of generic meropenem at high ambient temperatures and various concentrations in solution.Methods: Generic meropenem brand A and brand B vials were used to prepare 10 mg/mL and 20 mg/mL solutions in PVC bags. The prepared solutions were incubated at 25, 30 and 35 °C. Three mL of each solution were with drawn at 0, 4, 8 and 12 hours and subjected to HPLC analysis.Results: Generic meropenem (Brand A) as a 10 mg/mL solution was stable for up to 10 hours at 25°C, 5 hours at 30°C and 4.5 hours at 35°C. A. 20 mg/mL solution was stable for 6 hours at 25°C, 5 hours at 30°C and 3 hours at 35°C. Generic meropenem (Brand B) as a 10 mg/mL solution was stable for up to 9 hours at 25°C, 5 hours at 30°C and 3 hours at 35°C. A. 20 mg/mL solution was stable for 5 hours at 25°C,10 hours at 30°C and 5 hours at 35°C.Conclusion: The stability of the generic meropenem solutions was affected by temperature and concentration. Higher the temperatures and higher the drug concentrations, show lower the stability of generic meropenem.Â
Authors and Affiliations
Wasan Katip, Purida Wientong, Chuleegone Sornsuvit
Keywords
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