The study of adverse drug reactions (ADRS) of antiretroviral therapy (ART) on HIV infected persons (PLHIV) at our Art Centre, Jodhpur, Rajasthan
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 3
Abstract
Antiretroviral drugs are successful in controlling HIV/AIDS and reducing disease progression. Antiretroviral regimens are stopped in up to 25% of all patients during their initial treatment therapy as a result of adverse drug effects, failing treatment and non adherence within the initial eight months of treatment. A pharmacovigilance surveillance system makes it possible for physicians, pharmacists and other healthcare providers to report suspected ADRs. The objective of this study was to assess the prevalence and severity of Adverse Drug Reactions (ADRs) among HIV/AIDS patients at ART centre, Jodhpur. In our study, 595 patients were included for study of ADRs of the ART for period of one year. These patients were interviewed and examined in each follow-up visits for ART related problems or Opportunistic Infections (OIs). Of the 595 patients, only 120 patients were developed total 188 ADRs. In this study, adverse drug reactions were observed to be present more in males as compared to females and majority of the patients were in the age group of 31-45 years. Incidence of ADRs was 20.16% (120/595). Most commonly encountered side effects were hematological (26.59%), gastrointestinal (20.74%), cutaneous (18.61%), neurological (8.51%) and musculoskeletal (7.97%). Causality assessment by Naranjo’s scale, most of ADRs was ‘possible’ (62.76%). Severity assessment showed that most of the reported ADRs 11.6% were mild and 85.2% were moderate in nature while 4.2% was life threatening. This concluded that earlier ART initiation, before the development of a low CD4 cell count and opportunistic infection, may reduce the incidence of adverse effects. Keywords: Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Antiretroviral Therapy, Adverse Drug Reactions, Hematological Disorders, Gastrointestinal Disorders.
Authors and Affiliations
Dr. Ateendra Singh, Dr. Anamika Singh, Dr. Omi Chouhan, Dr. Anusuya Gehlot, Dr. Gyan Prakash Tandi, Dr. Mitali Dua
Keywords
Related Articles
- EP ID EP370916
- DOI -
- Views 82
- Downloads 0
Middle Cerebral Artery Doppler Indices in Preeclampsia for Prediction Fetal Outcome
Abstract: Hypertension disease is a major cause of maternal mortality; it's also responsible for perinatal morbidity and mortality mainly due to its effect on the growing fetus. Preeclampsia (PE) which is characterized b...
Assessing Utilisation of Primary Health Care Services in Essien Udim, Nigeria: Pinpointing Determinants and Implications
Abstract: Good health is a key inalienable right of all Nigerian citizens but, guaranteeing this right often comes short. This is underscored by Nigeria’s health indices that have remained below global standards. The lev...
The Study of Serum Calcium and Vitamin D Levels in Preeclampsia and Pregnancy Induced Hypertension
Abstract: Recent evidences suggest a high prevalence of calcium and vitamin D deficiencies in preeclamptic women. However, level of these parameters in pregnancy induced hypertension has not been studied thoroughly. So t...
Management of Pilonidal Disease in a District General Hospital: Our Experience and Review of the Literature
Our study was a retrospective analysis of pilonidal disease management in Stafford Hospital, a District General Hospital. We analyzed 80 patients which included 44 men and 36 women who presented with pilonidal disease (s...
Semi-Quantitation of Urokinase Plasminogen Activator System (uPAS), And Bcl3 in Breast Tumors
Abstract:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. This study was aim to investigate the eval...