THE STUDY OF CHANGES IN SERUM ELECTROLYTES (Na+, K+, Ca++, Mg++) IN ALUMINIUM PHOSPHIDE POISONING PATIENTS- IS THERE ANY CORRELATION WITH MORTALITY OR SURVIVAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 21
Abstract
BACKGROUND Aluminium phosphide (ALP), a solid fumigant pesticide was declared as an ideal fumigant pesticide in 1973 because of its effectiveness, low cost and ease to use. Its toxic effects on humans are due to liberation of toxic phosphine (PH3) gas on contact of moisture and HCL in stomach after ingestion leading to cellular toxicity and death. MATERIALS AND METHODS The present descriptive comparative study comprised of 42 acute aluminium phosphide (ALP) poisoning patients without prior intervention admitted in medical emergency of GSVM Medical College, Kanpur. The details of history and physical examination was recorded, and relevant lab investigations were done. The serum electrolytes were evaluated at the time of admission before any treatment in all the ALP poisoning patients. There were 35 healthy control subjects evaluated for serum electrolytes measurement. RESULTS The study of 42 acute ALP poisoning patients showed hyponatraemia in 30% cases, hypokalaemia in 90%, hypocalcaemia and hypomagnesaemia in 75% each and these changes were statistically significant. The 14 patients who expired had decreased serum Na+ levels in 21.42% cases and in 78.51% cases were having hypokalaemia, hypocalcaemia and hypomagnesaemia each. In the 28 survived patients, hyponatraemia was seen in 42.85% cases, hypokalaemia in 92.85% cases, hypocalcaemia and hypomagnesaemia in 71.43% cases. There was no statistically significant difference between the serum Na+, K+ and Ca++ values of expired and survived patients. However, serum Mg++ level was higher in expired patients than the survived patients, but it was less than the control subjects. CONCLUSION In the study, various significant electrolytes changes were found in the ALP poisoning patients. But as evident from the study, there is no correlation between serum electrolytes levels and mortality or survival of ALP poisoning patients.
Authors and Affiliations
Arvind Kumar, Prem Singh, Tanu Midha
Keywords
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- EP ID EP431638
- DOI 10.14260/jemds/2018/581
- Views 66
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