The Study of Metabolic Syndrome in Obese Persons
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background: The metabolic syndrome is a constellation of risk factors of metabolic origin that are accompanied by increased risk for cardiovascular disease and type 2 diabetes. The two major underlying risk factors for the metabolic syndrome are obesity and insulin resistance; exacerbating factors are physical inactivity, advancing age, and endocrine and genetic factors. The condition is progressive, beginning with borderline risk factors that exactly progress to categorical risk factors. Indians have a characteristic obesity phenotype, they have relatively low BMI with abdominal obesity. Fat distributed in the abdominal region is more metabolically significant than other fat depots. Various studies shows that increased abdominal(visceral) fat accumulation is an independent risk factor for CAD, hypertension, stroke, and type 2 diabetes there b leading to metabolic syndrome. However there is paucity of data and studies regarding the relationship between abdominal obesity and metabolic syndrome in our part of country. Aim : The aim of this study was to study the relationship between abdominal obesity and metabolic syndrome. Materials And Method: A total of 100 patients with abdominal obesity (waist circumference > 102 cm in males.> 88.0 cm in females) were enrolled for this study between July-2014 to June-2016 are included in the study. Results: Of the total 100 subjects, 57 males and 43 females, 71% had MS. 68% had systolic BP>135mmhg, 52% had diastolic BP> 85 mmhg, 68% were on anti hypertensive drugs, 20% were on insulin treatment, 20% were on oral hypoglycemic. 91% had fbs more than 100mg/dl. The mean level of total cholesterol , LDL cholesterol, triglyceride is increased whereas the mean level of anti-atherogenic HDL cholesterol is low in subjects with MS Prevalence of MS significantly high in older age groups. Age is positively associated, alcohol use is negatively associated, HDL(decreasing) and triglycerides are positively associated with the incidence of metabolic syndrome, patients of diabetic treatment are more likely to develop metabolic syndrome, Waist circumference is the better predictor of MS when compared to BMI independently.
Authors and Affiliations
Shree Vashista, K Goel, Ritesh Lal
Keywords
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