THE STUDY OF MICRONUCLUES INDEX IN PATIENTS PRESENTING WITH MALIGNANT LESIONS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 33
Abstract
Micronucleus is the nucleus that expresses the genotypic alterations caused in the process of malignancy. It is characteristically seen in exfoliated epithelial cells like Buccal Mucosa and urinary bladder wall during pre-cancerous and cancerous conditions in less and large proportions respectively. It is commonly used as a Biomarker to assess the stage and severity of neoplasm. Aim of our study is to observe the micronucleus Index in patients presenting with malignant oral lesions. 30 patients with malignant lesions from the Department of oral medicine, Vydehi Institute of Dental Sciences and Research Centre were screened for the presence of micronucleus. The buccal scrapings were obtained from the site of the lesion in the oral cavity by conventional methods. The obtained slides were stained by using Haematoxylin& Eosin stains and the micronucleus index was calculated. The results showed that the alteration of micronucleus count was observed in malignant conditions with respect to age and gender. Hence it can be concluded that the micronucleus index can be used as a biomarker or as a screening test in patients presenting with pre malignant conditions.
Authors and Affiliations
Archana R.
Keywords
Related Articles
- EP ID EP230279
- DOI 10.18410/jebmh/2015/699
- Views 94
- Downloads 0
BIOPHYSICAL PROFILE OF BLOOD PRESSURE IN URBAN HEALTHY SCHOOL CHILDREN- A CROSS SECTIONAL STUDY
BACKGROUND Hypertension is a chronic non-communicable disease with high morbidity and mortality. Prevailing number of hypertensives diagnosed in society indicate just the tip of iceberg as it was documented that almost 7...
DIAGNOSTIC VALUE OF ADENOSINE DEAMINASE ACTIVITY IN TUBERCULOSIS & NON TUBERCULOUS LYMPHOCYTIC BODY FLUIDS
INTRODUCTION The diagnosis of tuberculosis continues to be a challenge. More than 90% of TB effusions show a lymphocytic predominance, hence TB requires exclusion in any lymphocytic exudative effusion where no alternativ...
TO COMPARE CT PERIPHERAL ANGIOGRAPHY AND NON ENHANCED MAGNETIC RESONANCE PERIPHERAL ANGIOGRAPHY IN EVALUATION OF PERIPHERAL VASCULAR DISEASES
BACKGROUND Computed tomography Peripheral angiography (CTPA) and Non enhanced magnetic resonance angiography (NE-MRA) are accurate techniques for selecting patients with peripheral arterial disease for surgical and endov...
A CORRELATIONAL STUDY BETWEEN CHANGES IN SERUM ELECTROLYTES (NA, K, CL, MG) AND ACUTE MYOCARDIAL INFARCTION COMPLICATION
BACKGROUND The term "arrhythmia" refers to any change from the normal sequence of electrical impulses. The electrical impulses may happen too fast, too slowly or erratically causing the heart to beat too fast, too slowly...
AN OBSERVATIONAL CLINICAL STUDY OF ASSESSING THE UTILITY OF PSS (POISON SEVERITY SCORE) AND GCS (GLASGOW COMA SCALE) SCORING SYSTEMS IN PREDICTING SEVERITY AND CLINICAL OUTCOMES IN OP POISONING
BACKGROUND Organophosphorus compound poisoning is the most common poisonings in India because of easy availability often requiring ICU care and ventilator support. Clinical research has indicated that respiratory failure...