The study of serum uric acid level in acute ischemic stroke
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 9, Issue 3
Abstract
Background: It is uncertain whether high uric acid concentrations assist or defend against the occurrence of cardiovascular diseases, or simply act as latent marker of increased risk in contest with such controversy and inadequate available Indian data, it is necessary to carry out further research over the role of uric acid level in patient of acute ischemic stroke. Method: 100 cases of acute ischemic stroke were studied along with risk factors for stroke were noted such as hypertension, diabetes mellitus, dyslipidemia, alcohol, smoking. Serum uric acid levels were measured in all cases. Statistical analysis was performed with of SPSS 22.0 software. Results: Out of 100 patients 66% were males and 34% were females. Male to female ratio is 1.9. Mean age of 63.13years. The prevalence of hyperuricemia in stroke patients was 37%. Mean SUA was 6.02±1.70mg.Out of 37 hyperuricemic patients,25(67%) were above the age of 60 as compared to patients with normal serum uric acid in whom 31(49%) out of 63 patients were above the age of 60 and there was no significant relationship in between age and uric acid in acute ischemic stroke patients.(p>0.05).SUA level amongst male patients was 6.07±1.67mg/dl and in femalewas 5.92±1.78mg/dl. The difference in SUA level and gender is not stastically significant(p>.0.05). Total 72% of patients were hypertensive and out of 37 hyperuricemic patients 32(86%) were hypertensive and there was a significant association between hyperuricemia and hypertension in patients with acute ischemic stroke. (p<0.05). Among diabetic the mean SUA is 6.20±1.66mg/dl. While in non-diabetic patients 5.94±1.72mg/dl. No significant association between diabetics and non- diabetic. There was no statistically significant relationship found between hyperuricemia and dyslipidemia. (p>0.05). Mean SUA level among dyslipidemic patients was 6.07± 1.65mg/dl, while in normal patients was 5.96±1.77 mg/dl. Mean SUA level among alcoholic was 5.68±1.61 mg/dl as compared to non-alcoholics in which it was 6.16±1.73mg/dl. Mean SUA level amongst smokers was 6.03±1.55mg/dl. vs 6.01±1.79mg/dl amongst non-smokers. Conclusions: The association between hyperuricemia and acute ischemic non embolic stroke may be considered while treating the hypertensive population. Hyperuricemia can be considered as one of the significant and independent risk factor for acute ischemic non- embolic stroke.
Authors and Affiliations
M G Pattewar, C D Awalekar
Keywords
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- EP ID EP517199
- DOI 10.26611/10219315
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