The study of the technological and microbiological parameters of a dietary supplement “Оsteovert”

Journal Title: Вісник фармації - Year 2018, Vol 94, Issue 2

Abstract

The main tasks of the treatment of rheumatologic diseases include minimizing pain and inflammation in the joints, as well as restoring their functions. Duration of the treatment and the chronic course of the disease make it difficult to carry out the anti-inflammatory and analgesic therapy, which is characterized by the negative impact of non-steroidal anti-inflammatory drugs (NSAIDs) on an articular cartilage, as well as on organs of the gastrointestinal tract. In this regard, it is important to create new effective and safe products of plant origin, which use involves fewer side effects and the possibility of a longer period of use.Aim. To study the technological and microbiological parameters of the combined drug – a dietary supplement “Оsteovert” in soft gelatin capsules for use in rheumatology and a dry extract of harpagophytum (Harpagophytum procumbens) used in its production.Materials and methods. The choice of active components in the composition of a dietary supplement “Оsteovert” in soft gelatin capsules was substantiated by the analytical review of drugs used in diseases of the musculoskeletal system and presented at the pharmaceutical market of Ukraine, as well as by the results of the own pharmacological studies.Results and discussion. The research on studying the technological parameters of soft capsules “Оsteovert” promoting improvement of the condition of the musculoskeletal system has been conducted. The active ingredients of capsules are glucosamine sulfate, chondroitin sulfate and a dry extract of harpagophytum roots. According to the methods of the State Pharmacopeia of Ukraine (SPhU) the following pharmacotechnological tests of a dry extract have been conducted: the fractional composition, fluidity, which is characterized by determining the angle of repose and the emptying time, the bulk volume and settled volume, settling qualities and density (bulk density and tapped density). In order to develop the specifications of Ukraine for capsules the organoleptic indicators, uniformity of mass for a unit of a dosed drug and disintegration have been determined. The microbiological indicators of intermediate products and capsules “Оsteovert” meeting the requirements of the current regulatory documentation have been determined. The material balance of the batch of capsules “Оsteovert” has been calculated.Conclusions. The pharmacotechnological parameters of a dry extract of harpagophytum have been studied according to the methods of the SPhU. The results of the study were used when substantiating the choice of a dosage form for a dietary supplement “Оsteovert”. The manufacturing technology and the flowchart for the manufacturing process of capsules “Оsteovert” intended for use in diets as an additional source of glucosamine, chondroitin and harpagoside have been developed. The microbiological quality parameters have been determined for the capsules and the dry extract of harpagophytum obtained. The manufacturing technology for capsules “Оsteovert” has been implemented in production at the PJSC “DNCLZ Pilot plant”.

Authors and Affiliations

A. I. Kriukova, I. M. Vladymyrova

Keywords

Related Articles

Analysis of approaches to pharmacotherapy of patients with cardiovascular diseases according to the data of the Ukrainian and British Formularies

Aim. To analyze the approaches to pharmacotherapy of patients with cardiovascular diseases (CVD) indicated in the State Formulary of Medicines of Ukraine (SFMU) and the British National Formulary (BNF), as well as the re...

Маркетингові дослідження українського фармацевтичного ринку препаратів для лікування артриту

Ревматоїдний артрит (РА) – хронічне системне захворювання сполучної тканини з ураженням периферичних суглобів і характерними позасуглобовими проявами. Ревматичні хво-роби впливають на національну економіку, призводять до...

Дослідження елементного складу трави маруни дівочої (Tanacetum parthenium (L.) Schultz bip.)

Макро- та мікроелементи впливають на життєві функції рослин, є невід’ємною складовою лікарської рослинної сировини і відіграють значну роль у фармакологічній активності рослинних лікарських засобів. Доцільність визначенн...

Выбор количественного состава вспомогательных веществ при создании пасты цеолита природного

Свойства паст зависят от ряда факторов, важнейшими из которых являются концентрация твердой фазы и природа дисперсионной среды.Цель работы. Изучить влияние количеств действующих и вспомогательных веществ на фармакотехнол...

Разработка методик контроля качества действующих ингредиентов геля венотонизирующего действия

Цель работы. Разработка методик контроля качества биологически активных веществ жидких экстрактов семян каштана конского обыкновенного и корней окопника – основных составляющих новой лекарственной формы в виде геля венот...

Download PDF file
  • EP ID EP666221
  • DOI 10.24959/nphj.18.2206
  • Views 107
  • Downloads 0

How To Cite

A. I. Kriukova, I. M. Vladymyrova (2018). The study of the technological and microbiological parameters of a dietary supplement “Оsteovert”. Вісник фармації, 94(2), 41-47. https://europub.co.uk/articles/-A-666221