THE STUDY OF UTILITY OF CBNAAT IN DIAGNOSING PULMONARY TUBERCULOSIS IN HIV POSITIVE PATIENTS IN NORTH KARNATAKA
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 19
Abstract
BACKGROUND Tuberculosis being a global burden, there is a need for early detection and treatment of pulmonary TB. CBNAAT is used as rapid diagnostic test and it is a highly efficient. Twenty five percent of global annual TB incidents occur in India making it the highest Tuberculosis burdened country. We wanted to study the role of CBNAAT in early the diagnosis of tuberculosis/multi-drug resistant tuberculosis in HIV seropositive subjects and compare the detection of M. tuberculosis in sputum by CBNAAT with conventional sputum microscopy in pulmonary tuberculosis. METHODS Patients who presented with persistent cough for more than two weeks, chest X ray suggestive of PTB were subjected to sputum examination by routine microscopy and cartridge based nucleic acid amplification technique (CBNAAT). RESULTS CBNAAT had a sensitivity of 100%, specificity of 79.31%, PPV of 41.94% and NPV of 100% and diagnostic accuracy of 82%, whereas sputum microscopy showed only 41.94% sensitivity. CONCLUSIONS CBNAAT helps in early detection of tuberculosis, takes less than 2 hours, and is more sensitive in detecting tuberculosis in HIV sero-positive cases compared to sputum microscopy and reduces the false negative rates. Drug resistance can concomitantly be identified.
Authors and Affiliations
Ameet Vasantrao Khatawkar, Nagaraj Talikoti, Prashant Kumar Malkiwadeyar, Md. Juned, Veeresh Basavaraj Hubballi, Ganeshgouda Majigoudra, Mohith H. N, Shravan Kumar Potkar
Keywords
Related Articles
- EP ID EP619812
- DOI 10.18410/jebmh/2019/298
- Views 69
- Downloads 0
CLOSURE OF RECALCITRANT TRACHEOCUTANEOUS FISTULA-BY USING TURN OVER PLATYSMAL MUSCLE FLAPS
BACKGROUND The objective of the study was to determine efficacy of repair of recalcitrant tracheocutaneous fistula with the use of medial based turnover platysma muscle flaps; providing a double layer covering to the fis...
MANAGEMENT OF SICKLE CELL DISEASE
Sickle cell disease (SCD) is a genetically transmitted multisystem disease1 which includes a group of disorders that differs in severity sign and symptoms, The disease is not uniformly seen everywhere but it has some top...
CLINICAL STUDY OF ACUTE SCROTAL SWELLING
BACKGROUND Acute scrotal swellings though commonly encountered, many a times an accurate diagnosis is not made and the precious testis is sacrificed. In this study we find out the incidence of etiological factors which c...
THE EFFECT OF PARITY, BISHOP SCORE AND CERVICAL LENGTH BY TRANSVAGINAL ULTRASOUND IN PREDICTION OF INDUCTION TO DELIVERY INTERVAL
To evaluate the role of parity, Bishop score, cervical length by transvaginal ultrasound in predicting the induction to delivery interval. METHODS AND MATERIALS: It is a prospective study done at Government general Hospi...
A STUDY ON THE PREVALENCE AND RISK FACTORS FOR HYPOTHYROIDISM IN LITHIUM TREATED BIPOLAR DISORDER PATIENTS
BACKGROUND Lithium is a novel mood stabilizer in the treatment of bipolar disorders. Toxic effects are frequently encountered in clinical practice due to its narrow therapeutic index. Thyrostatic effects especially clini...