The testing of an artificial modified bacterial cellulose auricle skeleton in an animal model
Journal Title: Polish Journal of Surgery - Year 2019, Vol 91, Issue 2
Abstract
The aim of this study was to assess whether modified bacterial cellulose can be used for an artificial auricle skeleton. Introduction: The auricle is a part of the external ear. It consists of skin, cartilage, muscles and adipose tissue. The cartilage gives shape to the structure. There are several indications for reconstruction, such as congenital anomalies, mechanical injuries, and burns, and a range of methods have been proposed for the complete reconstruction of the auricle. Material and methods: A bacterial cellulose membrane, at least 25 mm in thickness, was produced in vitro by Acetobacter xylinum culture. The entire artificial human auricle skeleton was made to scale to allow its implantation into an animal model - Wistar rats. Forty rats were divided into four groups of 10 animals. Each group was assigned a different resection time: 14 days, 30 days, 90 days or 720 days. After each resection, an examination of the artificial skeleton and the tissues surrounding it was conducted. The surgical procedure was based on the Nagata technique. Results: Resection after 14, 30, 90 and 720 days shows the progression of the healing process and integration of the artificial skeleton into the animal body. There are no signs of change in the shape or structure of the skeleton. Discussion: Several surgical techniques and biotechnological methods have been developed over the past few years to improve the results of facial reconstruction. Other approaches can be used to create auricle cartilage, based on scaffolds and chondrocytes. Conclusion: My findings indicate that modified bacterial cellulose can be used to form an effective artificial auricle which appears to maintain its shape and elasticity, with no signs of degradation.<br/><br/>
Authors and Affiliations
Stefan Miśkiewicz, Bartlomiej Grobelski, Zbigniew Pasieka, Marta Miśkiewicz
Keywords
Related Articles
- EP ID EP435670
- DOI 10.5604/01.3001.0012.8551
- Views 134
- Downloads 0
Roux-en-Y gastric bypass as a cure of iatrogenic – steroid induced diabetes
Background Steroid induced diabetes (SIDM) is a frequently found clinical condition since steroid-based therapies continue to be widely used in hospital and ambulatory care. Recommended optimal treatment of SIDM include...
Long-term results of partial nasal reconstructions with indian fl
The aim of the study was clinical evaluation of the results following reconstruction with the Indian flap in patients with partial nasal defects, and estimation of their postoperative life quality in functional and aesth...
Gall-Bladder Duplication - Case Report
Gall-bladder duplication is a rare anatomical variation, which can affect safe performance of cholecystectomy and be a cause of persistent symptoms and a need for reoperation in case of accessory gallbladder omission. A...
Laparoskopowe resekcje żołądka z usunięciem preparatu przez usta w leczeniu guzów śródściennych żołądka
Cel: Celem pracy jest przedstawienie doświadczeń i wczesnych wyników leczenia guzów żołądka z zastosowaniem techniki usunięcia preparatu operacyjnego przez usta (POSE - per oral specimen extraction).. Materiał i Metodyka...
Comparison of lymphatic system staging classifications in patients with gastric cance
Despite an observed decrease in the incidence of gastric cancer, it still remains an important clinical problem. It is the fourth most common cancer in the world and the second cause of death in cancer patients. The qual...