THE THE INFLUENCE OF THE EXCIPIENTS ON THE ANTI-INFLAMMATORY EMULGEL BIOPHARMACEUTICAL QUALITY PARAMETERS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objective: Boswellia serrata dry extract (BSDE) has clinically proved its anti-inflammatory, anti-gout, and analgesic effect. In the course of this study, compositions and technologies of the emulgels, containing dry Boswellia extract, were developed. Materials and Methods: Rheological characteristics of gels were determined with rotational viscosity method using coaxial rotation viscometer Lamy Rheology RM 200. The stickiness was determined using a lever mechanism which separates two preprocessed glass plates of the same area from each other. Spreadability was determined with a weighted amount of gel placed on a glass plate (10 cm × 10 cm), covered with a cover glass of the same size and a 100 g measuring plane placed on top of it. Results: The composition containing 20% of turpentine oil was shown to have the highest yield strength, which can positively affect the aggregative stability of the dosage form. The spreadability of all samples lies within the average value of the spreadability of the commercial gels. The stickiness of all samples was determined to be in the range from 3.6 to 4.9 N. The composition containing turpentine oil showed maximum stickiness after application and its minimum decrease by 5 min. Conclusion: The advantages of the composition including turpentine oil as a solvent for BSDE were experimentally established.
Authors and Affiliations
NATALIA B DEMINA , ELENA O BAKHRUSHINA , IVAN I KRASNYUK , MIKHAIL B KORNEEV
Keywords
Related Articles
- EP ID EP608988
- DOI -
- Views 109
- Downloads 0
STEROIDS IN THE TREATMENT OF CHRONIC DISEASES
Since their identification, which was almost 80 years ago, steroids have played a prominent role in the treatment of many disease states such as chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and in...
EVALUATION OF ANTICONVULSANT ACTIVITY OF PREMNA HERBACEA (ROXB.) ROOT EXTRACTS IN ISONIAZID AND STRYCHNINE-INDUCED CONVULSIONS
Objective: The present investigation was to evaluate the anticonvulsant potential of three different extracts of roots of Premna herbacea (Roxb.) in mice. The preclinical screening models such as isoniazid (INH)- and str...
A REVIEW OF BOTANY, MEDICINAL USES, AND BIOLOGICAL ACTIVITIES OF PENTANISIA PRUNELLOIDES (RUBIACEAE)
This study is aimed at providing a critical review of the botany, biological activities and medicinal uses of P. prunelloides. Documented information on botany, biological activities, and medicinal uses of P. prunelloide...
A CORRELATION BETWEEN THYROID STIMULATING HORMONE AND BODY MASS INDEX IN WOMEN WITH SUBCLINICAL HYPOTHYROIDISM IN NCR
ABSTRACTObjective: Weight gain is a characteristic feature of hypothyroidism. People with subclinical hypothyroidism (SCH) are also characterized by the sameis still unclear.Methods: Height and weight were calculated of...
AN AN OBSERVATIONAL STUDY OF PRESCRIPTION PATTERN OF DRUGS FOR OSTEOARTHRITIS IN A NORTH INDIAN MEDICAL COLLEGE
Objective: The objective of the study is to analyze the prescription pattern of drugs for osteoarthritis (OA) in a north Indian medical college collaborated with a tertiary care hospital. Methods: An observational study...