THE TOXICOKINETICS OF 2-METHYLNAPHTALENE IN RATS

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THE TOXICOKINETICS OF 2-METHYLNAPHTALENE IN RATS

Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2010, Vol 23, Issue 4

Abstract

[b]Background: [/b]The aim of the study was to evaluate the toxicokinetics of 2-methylnaphtalene (2-MN) during and after inhalation exposure.[b] Material and Methods:[/b] Male Wistar rats were exposed to 2-MN vapours at nominal concentrations of 200 or 400 mg/m3 in the dynamic inhalation chamber for 6 hours or 5 days (6 h/day). Blood samples were collected during and after exposure. Blood concentrations of 2-MN were estimated by gas chromatography using the headspace technique. [b]Results:[/b] During a 6-hour exposure to 200 or 400 mg/m3, blood 2-MN concentration increased rapidly within the first or second hour of exposure, respectively, after reaching a plateau. The elimination of 2-MN from blood followed an open two-compartment model. [b]Conclusion:[/b] 2-MN was rapidly eliminated from blood of the animals exposed by inhalation to 2-MN. During exposure, lung retention of the chemical was found to decrease. Under conditions of repeated 2-MN exposure, no significant systemic 2-MN accumulation could be observed.

Authors and Affiliations

RADOSŁAW ŚWIERCZ, WOJCIECH WĄSOWICZ, WANDA MAJCHEREK

Keywords

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EP ID EP150163
DOI 10.2478/v10001-010-0026-3
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