The use of Aglepristone in the treatment of pregnancy related diabetic ketoacidosis: description of a case in a bitch
Journal Title: JOURNAL OF ADVANCES IN AGRICULTURE - Year 2015, Vol 4, Issue 3
Abstract
Gestational diabetes mellitus (GDM) is a rare disease in dogs that depends from an endogenous insulin supply that is insufficient to meet the tissues demands for the action of diabetogenic molecules like progesterone (P4), estradiol, growth hormone (GH), placental lactogen and placental cytokines. This report describes for the first time a case of GDM complicated by ketoacidosis treated with the P4 receptor blocker aglepristone. In our case aglepristone seemed to increase insulin sensitivity, helping in the resolution of ketoacidosis and of diabetes mellitus. Aglepristone may represent an effective and well tolerated therapeutic option in case of GDM.
Authors and Affiliations
Daniela Callegari, Carla Bresciani, Ezio Bianchi, Valeria De Cesaris, Enrico Parmigiani, Virginia Bigaran
Keywords
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- EP ID EP652369
- DOI 10.24297/jaa.v4i3.5057
- Views 174
- Downloads 0
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