The use of cerebrospinal fluid C reactive protein and adenosine deaminase as diagnostic markers in differential diagnosis of meningitis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Meningitis is an important public health problem in developing countries with considerable morbidity and mortality. Early categorisation according to the aetiology of meningitis leads to specific treatment with better outcome. Cerebrospinal fluid (CSF) culture is the gold standard but is not easily available and expensive so a rapid but specific test to differentiate types of meningitis is the need of the hour. So this prospective study was carried out in a tertiary care hospital in Eastern India. 50 patients of meningitis based on clinical, radiological and biochemical profile were recruited and serum C reactive protein (CRP), CSF adenosine deaminase (ADA) & CRP were estimated and analysed with respect to conventional parameters. The mean value of serum CRP in pyogenic meningitis was 54.98 which were considerably higher than tubercular and viral counterparts. CSF CRP was also higher in these patients with a mean value 20.35. In tubercular meningitis the mean CSF ADA is 31.16 which were higher compared to other causes. Taking CSF ADA cut off >10IU/L, 17out of 19 patients had higher levels which was quite significant. The sensitivity, specificity, positive predictive value, diagnostic accuracy of CSF CRP is 94.12%, 100%, 100% and 98% respectively and that for CSF ADA is 89.47%, 96.77%, 94.44% and 94% respectively. So CSF ADA & CRP can be used as early and reliable markers to differentiate meningitis.
Authors and Affiliations
Soumya Sarathi Mondal
Keywords
Related Articles
- EP ID EP508227
- DOI -
- Views 58
- Downloads 0
Conservative Management of Cerebral Venous Angioma - A Difficult Alternative For Patient And Physician
Cerebral venous angioma, also referred to as a developmental venous anomaly is a congenital anomaly of the medullary vein, the vessel that drains into the transparenchymal venous stem. We describe a 7 year old male child...
Seizure Semiology and Imaging Correlation
Seizure is defined as paroxysmal event due to abnormal excessive hyper synchronus discharges from an aggregate of CNS neurons. Although variety of factors influence the incidence and prevalence of seizure, approximately...
Consumption Consuming the Bones…
Here we present a case of a 29 year old pregnant female who was referred in view of bicytopenia , and on investigation she was diagnosed to have myelodysplastic syndrome, and on further investigations she was found to ha...
Is prevention and control of cervix cancer a priority amongst future health care providers in India?
Despite being a preventable cancer burden, cervix cancer remains an important public health problem in India. Major reasons behind this are lack of awareness both in the health care providers and community as well as ava...
LDL/HDL Cholesterol Ratio - Significance in Prognosis of Acute Myocardial Infarction
Coronary artery disease emerged as the major cardiovascular disorders of the era, becoming the most common cause of premature death. Study of its risk factors and their association with complication helps in monitoring t...