The use of immunobiological monoclonal antibody-based drugs in nephrological practice
Journal Title: Нирки - Year 2018, Vol 7, Issue 3
Abstract
With various diseases of the kidneys, immunobiological monoclonal antibody-based therapy with a different mechanism of action is successfully used. These drugs include: rituximab (interaction with the CD20 receptor and elimination of B cells), eсulizumab (inhibition of C5 complement cleavage), burosumab (blocking fibroblast growth factor 23), adalimumab (anti-tumor necrosis factor α agent), abatacept (blocks co-stimulation of T cells by binding to CD80), fresolimumab (neutralization of transforming growth factor β). These drugs are used for systemic kidney diseases, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, kidney transplantation.
Authors and Affiliations
O. O. Melnyk
Keywords
Related Articles
- EP ID EP369516
- DOI 10.22141/2307-1257.7.3.2018.140208
- Views 104
- Downloads 0
Urinary organs: development and congenital defects
According to the latest reports on the congenital malformations, factors of hereditary genesis account for 23–40 % of cases, 50–51 % are of multiple factor origin, and 2–5 % are due to teratogenic effects. In the overall...
Successful Pregnancy in Patient with Stage 5Chronic Kidney Disease
.
European Association of Urology, 2017 Paediatric Urology Guidelines. Urological infections. Summary of changes
.
Infections of Urinary Tract in Children: 2012 Updating
.
Effective Antibiotic Therapy of Complicated Urinary Tract Infections
The article presents data from a study on the clinical and bacteriological efficacy and safety of Brakson (tobramycin) in the treatment of complicated urinary tract infections. The results demonstrated the feasibility of...