The use of metformin in patients with chronic kidney disease
Journal Title: Annales Academiae Medicae Silesiensis - Year 2017, Vol 71, Issue
Abstract
Diabetes is a disease that affects about 4% of the population, and its incidence has been growing steadily. Increasingly more young people have to face this illness, and therefore more people suffer from chronic complications. The most frequent disorder of diabetics is diabetes nephropathy. This complication makes people‘s lives very difficult – not only the life of the patients but also the doctors who must strongly restrict the base of pharmaceuticals which can be used by these patients. Metformin has become a hope for people suffering from diabetes. This medicine has many advantages such as a decrease in glycaemia through many mechanisms. Simultaneously, it does not expose diabetics to hypoglycaemia. It reduces the death rate and protects patients‘ hearts. Additionally, it positively influences body weight, and it is taken orally. Currently, this medicine is also recommended in pre-diabetes states. Unfortunately, the chronic disease of the kidneys which usually occurs during diabetes does not enable the use of metformin. According to the Polish Diabetes Association, the dose of metformin should be reduced by half in the third phase of chronic kidney disease. In next phases, metformin should be thoroughly abandoned. There are opinions about the positive influence of metformin on people suffering from kidney disorders. The above article summarizes the current knowledge of using metformin and analyzes the latest research which describe its functioning. Additionally, it confronts two stances about the use of metformin in chronic kidney disease.
Authors and Affiliations
Michalina Mąka, Ewa Olszańska, Katarzyna Dubielak, Magdalena Domek
Keywords
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- EP ID EP344619
- DOI 10.18794/aams/64312
- Views 89
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