The Use of Stem Cell Therapy in the Treatment of Primary Central Nervous System Lymphoma
Journal Title: Journal of Orthopaedic Science and Research - Year 2024, Vol 5, Issue 2
Abstract
Lymphomas are a broad category of cancers in which malignant cells form in the lymphatic system and they are among the most common cancers in the United States. Primary Central Nervous System Lymphoma (PCNSL) is a lymphoma affecting the structures which make up the central nervous system: the brain, spinal cord and meninges, with the pathology of most cases belonging to the diffuse large B-cell category. Neurocognitive symptoms of PCNSL range in severity and onset, depending on the location of the tumor and the health of the patient. The prognosis of PCNSL upon diagnosis is poor, with 5-year survival rates of around 33%, contingent on patient age, gender, race, initial health, presence of autoimmune disorders or other comorbidities and access to treatments. There is a clear role of Human Immunodeficiency Virus and Epstein-Barr Virus in lymphomagenesis, making these two diseases a major risk factor for the development of PCNSL. The treatments for PCNSL are most commonly high-dosage chemotherapy and whole brain radiation, with some cases requiring surgery. The exploration of the efficacy of autologous stem cell transplants in combination with high-dosage chemotherapy is an emerging area of study with great promise for the extension of overall survival rates and quality of life of PCNSL patients.
Authors and Affiliations
Courtney Condon1, Vincent S Gallicchio2*
Keywords
Related Articles
- EP ID EP740682
- DOI https://doi.org/10.46889/JRMBR.2024.5204
- Views 40
- Downloads 1
A Paradox Called Interwar
Interwar was a short and turbulent period that lasted barely 20 years. It spanned from the signing of the armistice at the end of the First World War (1918) to the beginning of the Second World War (1939) [1]. The fam...
Assessment of Radiation Safety Training, Practices and Knowledge amongst Canadian Orthopaedic Resident Training Programs
Objective: There is ample literature demonstrating significant health risks associated with radiation exposure, yet there is no standardized radiation safety training for Canadian orthopaedic surgery residents. This is t...
Operative Treatment of Patients with Fractures During COVID-19
Objective: The epidemic of COVID-19 virus in Serbia began on March 6, 2020 with the first confirmed positive test. The pandemic affected all spheres of life, especially the functioning of the health system. The newly int...
The Etiological Understanding of Spine Deformities in Patients with Neuromuscular Disorders
Purpose: The etiology understanding is the corner stone for proper management of the spine deformities in patients with neuromuscular disorders. Methods: Progressive spine deformities have been encountered in 71 patie...
Electromagnetic Fields (Including Microwaves) Can Lower the Immune Response and Even Change The DNA
This article was written to draw attention to the experimentally found facts that external electromagnetic fields (like microwaves) can not only lower the immune response; it can even change the type of species. This is...