The Use of Stem Cell Therapy in the Treatment of Primary Central Nervous System Lymphoma
Journal Title: Journal of Orthopaedic Science and Research - Year 2024, Vol 5, Issue 2
Abstract
Lymphomas are a broad category of cancers in which malignant cells form in the lymphatic system and they are among the most common cancers in the United States. Primary Central Nervous System Lymphoma (PCNSL) is a lymphoma affecting the structures which make up the central nervous system: the brain, spinal cord and meninges, with the pathology of most cases belonging to the diffuse large B-cell category. Neurocognitive symptoms of PCNSL range in severity and onset, depending on the location of the tumor and the health of the patient. The prognosis of PCNSL upon diagnosis is poor, with 5-year survival rates of around 33%, contingent on patient age, gender, race, initial health, presence of autoimmune disorders or other comorbidities and access to treatments. There is a clear role of Human Immunodeficiency Virus and Epstein-Barr Virus in lymphomagenesis, making these two diseases a major risk factor for the development of PCNSL. The treatments for PCNSL are most commonly high-dosage chemotherapy and whole brain radiation, with some cases requiring surgery. The exploration of the efficacy of autologous stem cell transplants in combination with high-dosage chemotherapy is an emerging area of study with great promise for the extension of overall survival rates and quality of life of PCNSL patients.
Authors and Affiliations
Courtney Condon1, Vincent S Gallicchio2*
Keywords
Related Articles
- EP ID EP740682
- DOI https://doi.org/10.46889/JRMBR.2024.5204
- Views 63
- Downloads 1
Schwannomatosis a Rare Entity: Classic Imaging features
Schwannomatosis is rare neurocutaneous disorder. It is characterised by multiple schwannoma without involvement of vestibular apparatus. Being genetically different from NF2, now considered third form of neurofibromato...
Examining the Psychometric Properties of the 10-Item Active Movement Scale (AMS) for Assessing Musculoskeletal Function in Adults
Objective: A movement screen is an efficient tool to evaluate movement patterns, detect potential dysfunctions and justify interventions aimed at improving musculoskeletal health. This study aimed to examine the reliabil...
Traveler’s Constipation: A Prospective Cohort Study
Objective: Traveler’s constipation, which is characterized by the occurrence of harder and less frequent stools during travel, might affect the travel experience of individuals worldwide. The aim was to investigate chang...
A Novel Bone Void Filler for Use in Prosthetic Joint Infections
Bone grafts and Bone Void Fillers (BVF) have multiple applications in total joint reconstruction surgeries. However, despite their widespread use, they are contraindicated in Prosthetic Joint Infections (PJI). A BVF devi...
Do not Miss a Pediatric Lateral Condyle Fracture- A Case Based Description of Neglected Case Managed with Good Outcome
Background: Lateral Condyle Fractures are the second most common fracture amongst the pediatric elbow fractures, which is usually neglected commonly due to parents not seeking timely medical help or clinician missing the...