The use of whole rat embryo culture as a technique for investigating potentialserum toxicity in recurrent miscarriage patients.
Journal Title: Human Reproduction (Oxford) - Year 2001, Vol 15, Issue 10
Abstract
Previously, the rat embryo model has been used as an experimental techniquein investigations of the aetiology of idiopathic recurrent miscarriage. The aim of the present studywas to validate it as a tool in the investigation of the aetiology of this condition. Subjects (n = 36)with a history of recurrent miscarriage were recruited from two dedicated recurrent miscarriage clinicsand compared with control women with at least one previous pregnancy resulting in a live birth (n = 23).Serum from each woman was used as culture medium in the rat embryo model. Cultured embryos were scoredfor growth and differentiation. No statistical difference was found in any parameter between the twogroups. Furthermore, patients from the recurrent miscarriage group whose serum demonstrated a trend towardslower scores, subsequently conceived and underwent uncomplicated pregnancies.
Authors and Affiliations
M J Hewitt, M K Pratten, L Regan, S M Quenby, P N Baker
Keywords
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