The value of umbilical cord blood bilirubin measurement in predicting the development of significant hyperbilirubinemia in healthy newborn
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 5
Abstract
Introduction: Hospital readmission for neonatal hyperbilirubsinemia is a cause of concern among clinicians in neonatal departments. While early Hospital discharge of neonates is currently recommended by the neonatologists, it carries the risk of delayed recognition of hyperbilirubinemia and the possibility of brain damage due to kernicterus. In our study we aimed to study whether umbilical cord serum (UCS) bilirubin values could predict the risk of significant hyperbilirubinemia requiring treatment in newborns. Patients and Methods: In a prospective study carried out at the Neonatal Department of Krishna institute of medical sciences (KIMS), umbilical cord serum (UCS) bilirubin was collected from 117 newborns who were categorized into three groups according to UCS bilirubin levels, 4mg/dl respectively. All demographic data was collected from all included newborns and compared among the three groups. Maternal and neonatal blood groups were checked as well cord hemoglobin and hematocrit concentration. The neonates were then followed by TcB at 24hrs, 48hrs & 72hrs of postnatal age and those who showed significant high TcB values according to the hour-specific nomogram, were then sampled by venous blood for total & indirect bilirubin levels. Significant hyperbilirubinemia was interpreted as the need for medical intervention in the form of phototherapy and/or exchange transfusion. Results of study: A cut-off value of neonatal hyperbilirubinemia in cord blood was 2mg/dl and the end point of the study was the need for treatment. The mean value for total bilirubin in cord blood was significantly higher among newborns whose bilirubin values required phototherapy. The specificity reached 94.2% with a negative predictive value (NPV) of 96.32%. At cut-off cord serum bilirubin level >4mg/dl, the specificity was 98.92% and the NPV was 99.1%. Conclusion: Cord blood serum bilirubin can be used as a useful screening test for predicting neonatal hyperbilirubinemia and allowing safe postnatal Hospital discharge.
Authors and Affiliations
Dr. SY Ingale, Dr. Palak Vaghela, Dr. Poojan Patel
Keywords
Related Articles
- EP ID EP585963
- DOI -
- Views 128
- Downloads 0
Extract Formulation and Effectiveness of Beta vulgaris L. as dental plaque solution disclosing
This study aims to determine the effect of bit tuber effectiveness in controlling the plaque compared to the commercially branded product. This review is an experimental design with randomized pretest and posttest contro...
Comprehensive assessment of tooth wear in children: A state wide representative survey in Andhra Pradesh, India
Aim: To assess the distribution and severity of tooth wear among children of Andhra Pradesh state, India. Study design: A descriptive cross sectional study was conducted by trained and calibrated examiner. Methods: A two...
Fundus changes in pregnancy induced hypertension
The aim of the research is to examine fundus changes in Pregnancy Induced Hypertension and the correlation between the changes, hypertension levels, and the severity of the disease. Observation study was done on all the...
Anemia in pregnancy: Epidemiology and it’s determinants
Background: Determinants are nutritional, biological & social which contribute poor pregnancy outcomes both for mother & her infant. With this background the present study was designed to assess severity of anemia in rur...
Oral hygiene aids in a rural community in Nigeria
Introduction: The mouth is the portal for life-sustaining water and food. It is also a primary mechanism for human communication. The purpose of using oral hygiene aids like chewing stick and toothbrush is to attain good...