The Way We Deviate from Baseline
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 11, Issue 2
Abstract
Inflammation can begin acutely or slowly. Inflammation accompanies a number of biological processes in pathology and physiology. The reason why we often conclude based on the rate of initial development of an inflammatory disease that we are soon to be restored to our basal conditions, safe and sound, remains unknown. Here, I present a hypothetical model of an ‘information’-generating system for the body and cell based upon an assumption that our immediate response to external stimuli consists of bodily and cellular responses. Upon the initiation of every stimulus, body and cell must deviate from baseline and then return to baseline. How much the body and cell can deviate from baseline is determined by the capacity of an ‘information’-generating system. The rate of increase in nitric oxide availability in a compartment may be a discriminating factor for the capacity of a cellular ‘information’-generating system.Inflammation is manifested during the course of almost all disease states. However, in some cases, inflammation can be recognized as a physiological process. It seems quite difficult to clearly identify inflammatory processes as physiological or pathological. This identification is exemplified in angiogenesis, which shares many aspects with inflammation. Angiogenesis occurs in the yolk sac, preceding all other processes of organogenesis; it accompanies recovery from traumatic injuries, and it is an aspect of the pathology of diseases as a process toward or a component of complications. We cannot live a complete life if we avoid inflammatory processes. In general, there is a case for acutely beginning inflammatory diseases of a good and fast recovery when there is a benign nature of diseases; however, we do not have such an outlook in the case of slowly progressing diseases. Strangely enough, a reason why we do and do not remains unclear. It has to be of interest why the hope for a fine and fast recovery can be abandoned if an inflammatory disease begins slowly and why we can conclude, based on the initial rate of disease development, that the nature of the disease will remain benign. We must have automatically recognized a difference between acutely beginning and slowly beginning diseases that should be reflected in a difference in numerical values for variables functionally dependent on time at a given time point near the very beginning of an inflammatory disease. Our constant automatic reaction to every prognosis must have been long cherished and supported by the truth of Nature and must be a clue to unraveling a true mechanism that leads inflammatory processes to various destinations.
Authors and Affiliations
Yumiko Tozawa
Keywords
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- EP ID EP592358
- DOI 10.26717/BJSTR.2018.11.002088
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