THEORETICAL-CHEMICAL-QUANTUM ANALYSIS OF SARIN NEUROTOXICITY
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 5
Abstract
Sarin is a potent chemical weapon as a neurotoxic agent. Its dominant toxicity, ease of dispersion in the air and natural degradation allows rapid deployment by an attacking force. The objective of this very theoretical research was to find the molecular interactions of sarin vs. nine neurotransmitters (NT) that are most important for the functioning of the human nervous system. We use the hyperchem software to perform the quantum calculations, and we rely on the theory of the electron transfer coefficient to perform the calculations. We find that sarin oxidizes the nine NT investigated. For this reason, this neurotoxic it must be prohibited in all its uses. We conclude that the neurotoxic compound affects GABA, Noradrenaline, and Acetylcholine, mainly in that order.
Authors and Affiliations
Dr. Manuel González-Pérez
Keywords
Related Articles
- EP ID EP626150
- DOI -
- Views 120
- Downloads 0
PHARMACOKINETICS AND TISSUE RESIDUES OF MARBOCYL IN NORMAL AND AEROMONAS HYDROPHILIA INFECTED CATFISH (CLARIAS LAZERA)
The pharmacokinetics of marbocyl were studied following intravenous and intramuscular (single and repeated) administrations. Following a single intravenous injection of 10 mg/kg body weight of marbocyl in normal catfish...
ANTIDIABETIC ACTIVITY OF ILER (Plectranthus scutellarioides (L.) R. Br.) LEAVES SUBFRACTIONS OF ETHYL ACETATE FRACTION IN ALLOXAN-INDUCED DIABETIC MICES
Iler (Plectranthus scutellarioides (L.) R.Br.) leaves of extracts ethanol were previously shown to antidiabetic activity and the ethyl acetate fraction showed the highest activity of antidiabetic. The present study was u...
PITTAVAH SIRA – A CRITICAL & CONCEPTUAL CORRELATION WITH MODERN SCIENCE
In human body the movement & exchange of materials is possible only by watery medium of living tissues. For this purpose the nature has provided vascular or Raktavaha Sansthan. Within this system Rakta, which has been co...
EVALUATION OF CASES OF CRYPTOCOCCUS NEOFORMANS ISOLATED FROM ENVIRONMENTAL FOCUS IN BRAZIL: SYSTEMATIC REVIEW
The species of the Cryptococcus neoformans are commonly observed in the environment, especially in places with high presence of birds’ excreta. This yeast, in turn, play na important role in public cryptococcosis agent....
EFFECT OF FLAXSEEDS ON ISOPROTERENOL INDUCED CARDIOTOXICITY IN RATS
The present study was performed to explore the potential effects of flaxseed against isoproterenol induced cardiotoxicity in rats. Forty rats classified into control negative group and isoproterenol induced cardiac toxic...