Therapeutic Approaches to Drug Targets in Leukemia
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2014, Vol 1, Issue 1
Abstract
Non-communicable diseases like cancer are responsible for major social and health burden as millions of people are dying every year. Out of which, Leukemia is the leading cause of deaths worldwide. The ionizing radiation, chemotherapeutic agent and certain chemicals exposure are the risk factor for leukemia. Both genetic and environmental components are associated with the development of leukemia cells. Immune and inflammatory mediators have a complex role in the initiation and progression of leukemia. Understanding of all these processes will help to invent a range of new biomarkers and novel treatment modalities targeting various cellular events in acute and chronic inflammation that are accountable for leukemia. Several biochemical pathways, receptors and enzymes are involved in the development of leukemia that would be possible targets for improving strategies for disease diagnosis and management. However, the novel drug target like tyrosine kinase inhibitors, mcl-1inhibitor, jak-stat inhibitor, mTOR inhibitors, and mitogen-activated protein kinase (MEK) inhibitors, Heat shock protein inhibitors are more powerful to control the process of leukemia. Therefore, the review briefly focuses on different novel targets that act at starting stage in the formation of leukemia.
Authors and Affiliations
Mahesh Vitthal Rathod, Seema Vitthal Rathod
Keywords
Related Articles
- EP ID EP281029
- DOI -
- Views 63
- Downloads 0
A Review of Dhatu Pradoshaja Vikara
Human body is composed of Dosha, Dhatu and Mala among which Dhatus are more important structurally as they hold the body and perform specific functions like Prinana, Jivana, Lepana etc. Any kind of deformity in Dhatus ca...
Global Market Analysis of Herbal Drug Formulations
As per the WHO reports, about three-quarters of the world’s population currently use herbs and other forms of traditional medicines to treat disease. Even though marvelous advancement occurred in Allopathic system of med...
Ahara: Foremost Pillar of Ayurveda
Ahara is one of the three basic pillars of Ayurveda. It is one of the fundamental principles upon which happiness, health and harmony along with the natural law rest. The term ‘Ahara’ is concerned with diet and lifestyle...
Role of Uttara Vasti in Female Reproductive Disorders
In Ayurvedic Gynaecology, Sthanik Chikitsa are the specialized treatment procedures. These procedures basically deal with the disorders of Tryavarta yoni. Among these Uttara Vasti takes a specific place. In this study th...
Good Manufacturing Practices: A pathway towards quality ASU medicines
Ayurvedic medicines are being used from time immemorial for prevention and cure of human beings, therefore the efficacy and safety of these medicines is undoubted. However, the quality of these drugs is still a challenge...