Therapeutic Hypothermia
Journal Title: Global Journal of Anesthesiology - Year 2015, Vol 2, Issue 2
Abstract
Therapeutic hypothermia has been advocated for neuroprotection in cardiac arrest-induced encephalopathy, neonatal hypoxic-ischemic encephalopathy, traumatic brain injury, stroke, hepatic encephalopathy, and spinal cord injury, and as an adjunct to certain surgical procedures. In this review, we address physiological mechanism of hypothermia to mitigate neurological injury, the trials that have been performed for each of these indications, the strength of the evidence to support treatment with mild/moderate hypothermia. Evidence is strongest for prehospital cardiac arrest and neonatal hypoxic-ischemic encephalopathy. For traumatic brain injury, a recent meta-analysis suggests that cooling may increase the likelihood of a good outcome, but does not change mortality rates. For many of the other indications, such as stroke and spinal cord injury, trials are ongoing, but the data is insufficient to recommend routine use of hypothermia at this time. Although induced hypothermia appears to be a highly promising treatment, it should be emphasized that it is associated with a number of potentially serious side effects, which may negate some or all of its potential benefits. Prevention and/or early treatment of these complications are the key to successful use of hypothermia in clinical practice.
Authors and Affiliations
Durga Padmaja
Paediatric Analgesia during Inguino-Scrotal Surgery- A Pilot Study
Introduction: There are many different analgesic methods used for children undergoing inguino-scrotal surgery. Research suggests that caudal analgesia reduces the need for postoperative pain relief in these children comp...
Brochoscopy Intervention using Laryngeal Mask Airway in Infant for Severe Airway Stenosis
Fibreoptic bronchoscopy (FB) and laryngeal mask airway (LMA) have been used successfully in children since the early 1980s [1,2]. The paediatric fibreoptic bronchoscopy visa laryngeal mask airway (LMA) in general anesthe...
Emergent Cervical Decompression in a Child with MURCS Association
This case report describes an unusual presentation and anesthesia management of a rare genetic association. The MURCS association, a variant of Mayer-Rokitansky-Küster-Hauser syndrome is a rare (1/4500-1/50,000) congenit...
Combined Techniques in Difficult Airway Management
Difficult or failed tracheal intubation is an important cause of mortality and morbidity. Approximately 30% of anesthesia-related deaths are caused by the complications of difficult airway management. Also, 85% of respir...
Intravenous General Anesthesia for Patients with Neurological Disorders
In dental practice, intravenous general anesthesia is useful for patients who are difficult to treat when not sedated such as those with neurological disorders [1].