Therapy Interruption in Patients with Human Immunodeficiency Virus Infection — Two Cases Report
Journal Title: International Journal of Medical and Pharmaceutical Case Reports - Year 2017, Vol 9, Issue 5
Abstract
Sustained use of combination antiretroviral therapy (cART) has been shown to decrease morbidity, mortality and human immunodeficiency virus transmission. However, incomplete adherence and treatment interruptions (TIs) have emerged as major challenges to the effectiveness of cART. Currently clinical physicians at home and abroad still ask about the possibility of TIs for antiretroviral drugs and the effectiveness of resumptive treatment after TIs. This report provided experience sharing of two cases in our hospital for further discussions. Both of these patients were young men diagnosed with HIV infection and their conditions were stabilized after cART with HIV viral load (VL) below 50 copies/ml (Roche Amplicor v1.5) and CD4 counts as high as 600 cells/mm3. However, the patients inquired their physician to suspend their treatment due to quality of life concern. Their VL were significantly higher (>75 000 and 57 600 copies/ml) after their treatment were stopped four months and two months, respectively. Yet they started treatment again and their VL decreased rapidly to the instrument could not be detected (less than 400 copies/ml, Abbot Real Time) by the measured value of the situation 4 months later. As "treatment as prevention (TasP)" has become the AIDS treatment guidelines, it’s extremely important to not only minimize the occurrence of TIs but also be more active in dealing with the TIs issue.
Authors and Affiliations
Mei-Chun Lee, Chun-Ming Lee
Keywords
Related Articles
- EP ID EP309394
- DOI 10.9734/IJMPCR/2017/35585
- Views 142
- Downloads 0
Torsades De Pointes Induced by Methadone and Clonazepam Use
Background: While recent data showed that illicit drug use rates at six months of treatment with either methadone or buprenorphine were comparable among patients [1] and that slow-release oral morphine was not inferior t...
Ameloblastic Carcinoma of Mandible: Secondary Dedifferentiated Type
Ameloblastic carcinoma is a rare odontogenic malignancy. Ameloblastic carcinoma is a histopathological presentation, which combines the features of conventional ameloblastoma and cellular atypia. Biological behavior is r...
A Stroke of Undetermined Source in Geriatrics
Presentation of the Case: Criptogenetic strokes represent a challenge, particularly in geriatrics as the patient’s clinical complexity, the polipharmacotherapy, the epigenetic modifications of a life course may complicat...
Delusion of Pregnancy – Case Series of Seven Patients
Aim: The delusion of pregnancy involves neurophysiologic, endocrine, and traditional psychodynamic factors. This study investigated these factors in seven female patients with pregnancy delusions who were treated at the...
Neuroendocrine Tumour of the Appendix: A Case Report and Review of Literature
Neuroendocrine tumour of the appendix is a rare neoplasm discovered only incidentally. We hereby report an occurrence of this tumour in the appendix of a 27 years old female. There was an initial diagnosis of acute appen...