Abstract

The cancer treatment has been a challenge since it was diagnosed first. In that stage the primary focus centre of medicinal chemist was to combat a serious problem. So far many drugs have been approved for the cancer treatment, however, the side effects and resistance set them in corner. In pursuit of better drug candidate the first metal coordinating drug cisplatin came up with a wide range of anticancer activity. Metal coordinating drugs having anticancer activity open a new era of metal coordinating drugs. Efforts for the fine tuning of platinum coordinating anticancer compound leads to better option like carboplatin and oxaloplatin, however their resistance and some severe side effects made their limited use. The platinum drug has been modified in many ways to improve the safety profile as well the activity, moreover many derivatives were approved by the agencies. The endless efforts with the limited success turn the discovery to the different direction; in the recent scenario the existing drugs were modified to better pharmacokinetic parameters. The drug with improved pharamcokinetis parameter found less toxic compare to the parent drug, moreover among the modified drug some are going successfully in the clinical studies with the combination or alone. The ease of synthesis of these metal based molecules was an attraction for scientist to develop the structure activity relationship of the metal base core structure. Here in the focus is to highlight the importance of platinum in the cancer treatment with recent scenario. © 2018 iGlobal Research and Publishing Foundation. All rights reserved

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