THREE – COMPONENT REACTION OF 3 – NITRO BENZALDEHYDE, ISOPROPYL ACETOACETATE AND 1-BENZHYDRYLAZETIDIN – 3- YL - 2 AMINO – 2- IMMINOACETATE IN PRESENCE OF POTASSIUM CARBONATE: AN EFFICIENT ONE-POT SYNTHESIS OF 1, 4-DIHYDROPYRIDINE DERIVATIVE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 11
Abstract
A new and efficient one-pot synthesis of 1, 4 – dihydropyridine derivative by three component reaction 3 - Nitro benzaldehyde, isopropyl acetoacetate and 1-benzhydrylazetidin -3 - yl - 2 amino - 2 - imminoacetate in presence of dimethylformamide is described. The reaction was performed in dimethylformamide at 900C and mild basic condition.
Authors and Affiliations
B. Satyanarayana, P. Krishna, B. Sreenivasareddy , D. Ramachndran
Keywords
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