THROMBIN ENHANCES OVALBUMIN-SPECIFIC IGA IN MUCOSAL SURFACES BY INTRANASAL ADMINISTRATION IN MICE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 4
Abstract
Thrombin plays a central role in blood coagulation. In addition, thrombin is an important inflammatory mediator that activates T lymphocytes and monocytes and induces the release of proinflammatory cytokines in vitro. However, it has not been clarified whether thrombin can inducethe production ofantibodies against antigens in vivo; i.e., it is not known whether thrombin has an adjuvant effect to enhance immune responses. In the present study in mice, intranasally administered thrombin plus ovalbumin enhanced not only antigen-specificIgG in blood but also antigen-specificIgA on mucosa in the nasal cavity and intestine. IgA plays a major role in protecting against infection by preventing pathogens from invading the body through mucous membranes. This study provides new information regarding thrombin as an adjuvant of mucosal immunity.
Authors and Affiliations
Kazuyoshi Kaminaka, Chikateru Nozaki.
Keywords
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- EP ID EP563668
- DOI 10.21474/IJAR01/8781
- Views 74
- Downloads 0
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