THROMBOLYTIC AND MEMBRANE STABILIZING PROPERTIES OF METHANOLIC EXTRACTS OF AVICENNIA MARINA LEAVES & BARKS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 6
Abstract
The present study was commenced to judge ethnomedicinal worth of the plant. We tried to analyze in vitro thrombolytic and membrane stabilising activities of methanolic extracts of Avicennia marina. Crude methanolic extracts of A. marina leaves & barks at numerous conc. were used for in vitro thrombolytic and membrane stabilising activities. Just in case of thrombolytic study, it absolutely was dose dependently accumulated, wherever 10 mg/ml concentration most importantly showed 13.22% lysis of clot (p<0.001) by in vitro clot lysis assay technique. Streptokinase was used as standard & water was treated as negative management. Crude methanolic extracts of A. marina dose dependently increased in membrane stabilising study, whereas 10 mg/ml concentration most importantly showed 10.11% & 22.23% inhibition of haemolysis severally by both hypotonic solution and heat induced haemolysis of RBC membrane. Acetyl salicylic acid was used as standard in membrane stabilising study.
Authors and Affiliations
S. M. Naim Uddin , Md. Shalahuddin Millat , Israt Ira , Md. Mizanur Moghal , Muhammad Islam
Keywords
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- EP ID EP123338
- DOI 10.7897/2230-8407.07659
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