Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients

Journal Title: Annals of Hepatology - Year 2018, Vol 17, Issue 3

Abstract

Introduction and aim. Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a predisposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that develop thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis. Material and methods. We studied patients diagnosed with portal venous system thrombosis using contrast-enhanced computed tomography scan and doppler ultrasound at Medica Sur Hospital from 2012 to 2017. They were categorized into two groups; cirrhotics and non-cirrhotics. We assessed the hepatic function by Child-Pugh score and model for end-stage liver disease. Results. 67 patients with portal venous system thrombosis (25 with non-cirrhotic liver and 42 with cirrhosis) were included. The mean age (± SD) was 65 ± 9.5 years in cirrhotic group and 57 ± 13.2 years (p = 0.009) in non-cirrhotic group. Comparing non-cirrhotics and cirrhotics, 8 non-cirrhotic patients showed evidence of extra-hepatic inflammatory conditions, while in the cirrhotic group no inflammatory conditions were found (p < 0.001). 27 (64.29%) cirrhotic patients had thrombosis in the portal vein, while only 9 cases (36%) were found in non-cirrhotics (p = 0.02). Conclusions. In cirrhotic patients, hepatocellular carcinoma and cirrhosis were the strongest risk factors to develop portal venous system thrombosis. In contrast, extrahepatic inflammatory conditions were main risk factors associated in non-cirrhotics. Moreover, the portal vein was the most frequent site of thrombosis in both groups.<br/><br/>

Authors and Affiliations

Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nancy E. Aguilar-Olivos, Luis F. Alva-López, Ericka Fajardo-Ordoñez, Ileana Acevedo-Silva, Patrick G. Northup, Nicolas Intagliata, Stephen H. Caldwell, Guadalupe Ponciano-Rodríguez, Xingshun Qi, Nahum Méndez-Sánchez

Keywords

Related Articles

Gut microbiota and nonalcoholic fatty liver disease

Recent evidence has linked obesity and the metabolic syndrome with gut dysbiota. The precise mechanisms underlying that association are not entirely understood; however, microbiota can enhance the extraction of energy f...

Vaspin, resistin, retinol-binding protein-4, interleukin-1α and interleukin-6 in patients with nonalcoholic fatty liver disease

Background and rational. Data on newer adipokines and interleukins in patients with nonalcoholic fatty liver disease (NAFLD) are inconclusive. The primary aim of this study was the evaluation of serum vaspin, resistin,...

Incidence and prognostic factors associated with biliary atresia in western India

Aim: To estimate the incidence of Biliary Atresia(BA) amongst Neonatal Cholestatic Syndromes (NCS) and determine prognostic factors in BA patients who have undergone Kasai’s portoenterostomy. Study design- Retrospective...

Combined hepatocellular-cholangiocarcinoma (cHCC-CC): a distinct entity

Patients with hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, display a highly variable clinical course, suggesting that HCC encompasses several biologically distinct subtypes. This heterogeneity...

Download PDF file
  • EP ID EP345413
  • DOI 10.5604/01.3001.0011.7392
  • Views 80
  • Downloads 0

How To Cite

Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Nancy E. Aguilar-Olivos, Luis F. Alva-López, Ericka Fajardo-Ordoñez, Ileana Acevedo-Silva, Patrick G. Northup, Nicolas Intagliata, Stephen H. Caldwell, Guadalupe Ponciano-Rodríguez, Xingshun Qi, Nahum Méndez-Sánchez (2018). Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients. Annals of Hepatology, 17(3), 476-481. https://europub.co.uk/articles/-A-345413