Thrombotic complications – prevention and treatment of venous thromboembolism in cancer patients
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2012, Vol 6, Issue 2
Abstract
Patients with cancer have an increased risk of venous thromboembolism (VTE). There is evidence that the absolute risk of VTE in cancer patients depends on the type of cancer, stage of disease, treatment with chemotherapy, hormone therapy, immunomodulatory drugs (IMiDs), surgical procedures, the presence of an indwelling central venous catheter (CVC), age, immobilisation and length of anaesthesia. In these patients, risk factors may interact. In addition, cancer patients are at higher risk of recurrent VTE and bleeding than patients without cancer. Thrombotic complications have a significant impact on morbidity and, in some cases, also on mortality of patients with cancer; therefore, thromboprophylaxis to prevent VTE is needed. In some patients, venous thromboembolism may be the earliest symptom of an occult neoplasm. Furthermore, many patients who received a diagnosis of cancer within a year of VTE, already had distant metastases at the time of cancer diagnosis. The literature about the relation between cancer and venous thromboembolism was reviewed, with particular attention to risk factors of VTE in oncological patients, and connections between VTE and diagnosis of occult malignancy. Next, the prevention and treatment of venous thromboembolism in cancer patients is discussed. Finally, a potential anti-tumour and antimetastatic effect of anticoagulation and prognosis of these patients is described. Identifying high risk patients and the application of suitable prevention is the best way to reduce the incidence of VTE and its associated complications.
Authors and Affiliations
Monika Wójtowicz, Agata Rękas-Wójcik, Aleksandra Lipa, Wojciech Górski, Andrzej Prystupa, Jerzy Mosiewicz
Keywords
Related Articles
- EP ID EP58758
- DOI -
- Views 155
- Downloads 0
Non-alcoholic beverages, unknown influence on cell proliferation – an [i]in vitro[/i] study
Introduction and objective. The aim of the presented study was to check differences between ‘Diet’ and ‘non-Diet’ soft drinks on cell proliferation.Materials and methods. Coca Cola and Pepsi Cola of different origin and...
Abundance of questing ticks and molecular evidence for pathogens in ticks in three parks of Emilia-Romagna region of Northern Italy
Introduction and objective. Infectious and parasitic diseases transmitted by ticks, such as Lyme diseases, granulocytic anaplasmosis and piroplasmosis, have been frequently reported in Europe, with increasing attention t...
Borrelia burgdorferi genospecies detection by RLB hybridization in Ixodes cinus ticks from different sites of North-Eastern Poland
Introduction. RLB (Reverse Line Blot Hybridization) is a molecular biology technique that might be used for [i]Borrelia burgdorferi [/i]sensu lato (sl) DNA detection with genospecies specification. Among[i] B. burgdorfer...
Differences in health – a global problem and its various aspects
Annals of Agricultural and Environmental Medicine (AAEM) is the journal in the columns of which for many years the scope of problems has been discussed concerning the effect of environmental hazards on the human body. It...
<strong><em>Legionella pneumophilla</em> bacteria in thermal saline bath</strong>
Objective: The study was aimed at determining whether [i]Legionella pneumophila[/i] bacteria can be found in thermal saline waters used in balneotherapy. Methods: Water samples were collected from three thermal saline...