Thymectomy In Myastenia Gravis: Comparison With Conservative Therapy
Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 2
Abstract
Aim: To assess the efficacy of thymectomy on prognosis in myasthenia gravis (MG). Method: The demographical and clinical features of 40 thymectomised patients followed in our neuromuscular day clinic were analysed and compared to the patients' (54 patients) who were treated conservatively. The doses of all medications before and after TMT and at the beginning and during the last evaluation of CT, were noted. Prognosis is defined . Results: Both groups were identical for gender, mean follow-up period and distribution in Osserman grades except for their ages. The patients in the TMT group were much younger. No statistical relation was found between prognosis and the age at the time of operation, the age at onset of the disease, gender and the time from the onset of the disease until the operation. At the time of evaluation, the doses of prednisolone and pyridostigmin were lowered, azathiopirine was unchanged The ratio of the patients in the TMT group, taking no or very small amount of prednisolone was twice of that in CT group. At the last evaluation the ratio of patients who were better was 75% in the TMT group and 40% in the CT group. There was no mortality in the TMT group. Six patients deceased in the CT group. Conclusion: Results of the TMT group seems better than the CT groups'. Remarkable difference between the ages of the two groups and nonrandomisation of the patients may create bias in favor of TMT. Future larger studies involving identical patients are needed.
Authors and Affiliations
Muhtesem GEDIZLIOGLU, Pinar CE, Esra ARPACI, Demet CEVHER, Ahmet KULAN
Keywords
Related Articles
- EP ID EP102145
- DOI -
- Views 72
- Downloads 0
Progressive Multifocal Leukoencephalopathy in a Case Without Clear Evidence of Immunodeficiency
Introduction: Progressive Multifocal Leukoencephalopathy(PML) is a rare demyelinating disease of the central nervous system due to reactivation of a latent infection with JC papovavirus. PML predominantly occurs in sever...
Edaravone Leads To Increased Internal Luminal Vascular Circumference Following Subarachnoid Hemorrhage in An Animal Model of Vasospasm
Purpose: Cerebral vasospasm is the leading cause of morbidity and mortality following subarachnoid hemorrhage. Although a number of factors have been examined in clinical and experimental studies, the agent(s) responsibl...
Proton Magnetic Resonance Spectroscopy Findings Of Wilson’s Disease: Case Report
Magnetic Resonance Spectroscopy (single voxel) was applied in both the left and right basal ganglia of a patient clinically proven Wilson's disease. Decreased in NAA/Cr and Cho/Cr ratios was found and inverted lactate pe...
An Unusual Mechanism of Delayed Intracerebral Hemorrhage After Ventriculoperitoneal Shunting: Case Report
We present a case of delayed intracerebral hemorrhage that developed seven years after initial ventriculoperitoneal shunt surgery. A seven-year-old boy was admitted to emergency when he experienced sudden headache and vo...
The Relationship Between Cognitive Dysfunction and The Lateralization of The Motor Functions in Parkinson's Disease
Background: Parkinson's disease ( PD ) is a neurodegenerative disorder which starts with unilateral motor symptoms. During the clinical period, cognitive functions may deteriorate and dementia may occur. However, the rel...