Thyroid Associated Ophthalmopathy: Prevalence, Association & Risk Factors
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the retroocular tissues occurring in patients with Graves' disease. The aim of the present study was to determine the prevalence of TAO among Indian patients with thyroid dysfunction and the risk factors associated with TAO. This was a retrospective, hospital based and non-interventional study conducted at Department of Ophthalmology and General Medicine of two tertiary care centres. The duration of study was 6 months; January-2018 to June-2018. 50 adult patients (age >18 years) of thyroid disorder with orbitopathy were evaluated for possible inclusion in this study. An ophthalmologist interviewed the patients and noted the presence of symptoms and signs relevant to thyroid eye disease. Total 50 patients were eligible for study. Out of a total of 50 patients who were eligible for analysis, 38 were diagnosed with mild to moderate TAO and 12 were diagnosed with severe TAO. There were older patients among those with severe courses than in the group with mild to moderate courses (t-test, p = 0.007). There were more male patients in patients with a severe course (83.33%) compared to those with a mild to moderate course (63.15%), this difference was statistically significant. More patients with a severe course were smokers compared to those with a mild to moderate course. More patients with a severe course had a higher clinical activity score ( p = 0.006). Our study confirmed that smoking is the strongest risk factor for development of a severe course of TAO in Indian patients. Thus, it is important for patients with Graves' disease to refrain from smoking.
Authors and Affiliations
Pragya Jain, Abhishek Singhai, Harpal Singh, Rajesh Pattebahadur, Rajnish Joshi
Keywords
Related Articles
- EP ID EP475827
- DOI -
- Views 68
- Downloads 0
Study of association of Epstein Barr virus, LMP in Hodgkin lymphoma in south India
Hodgkin lymphoma is a lymphoproliferative malignancy. Originally described by Thomas Hodgkin in 1982. It has great potential for adding years of productive life by giving curative therapy as Hodgkin lymphoma are often cu...
Liver, spleen and renal sonographic abnormalities in adults with HIV/AIDS at Muhimbili National Hospital, Tanzania
Abstract: Abdominal involvement in HIV/AIDS is quite common. It is second to pulmonary disease. In resource limited countries, Ultrasound is widely available hence if used effectively can help to reduce abdominal complic...
A Study on Biofilm Production and Antibiotic Susceptibility Profile of Clinical Staphylococcus aureus Isolates in a Tertiary Care Hospital
Abstract: Staphylococcus aureus is one of the most important human pathogens and has been a leading cause of hospital and community acquired infections. Bacteria protected by biofilms are resistant to host defense mechan...
Retrospective Study of Effect of Smoking in Tibial Fracture Healing: An Original Study
The objective is to review the systemic impact of smoking on bone healing and the outcome on fracture of the shaft of the tibia in the age group of 18 to 60 years. Does smoking have a strong relation with fracture healin...
Are Laboratory Technicians Aware of Biomedical Waste Management and Biohazards?
Biomedical waste is hazardous to both humans and environment and is generated on a daily basis in almost all the laboratories. Minimization in production and appropriate disposal is equally important. The Ministry of Env...