Thyroid Dysfunction in Patients with Systemic Connective Tissue Disease
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2009, Vol 2, Issue 3
Abstract
Background. Alterations in the circulating thyroid hormone concentrations constituting the euthyroid sick syndrome (ESS) are frequently associated with systemic non-thyroidal diseases such as systemic connective tissue disease (SCTD). Aim. to elucidate the pattern of thyroid dysfunction in patients with SCTD. Subjects and Methods. Thirty patients with systemic lupus erythematosus (SLE) and thirty rheumatoid arthritis (RA) patients in addition to 30 healthy age- and sex- matched controls were recruited from the Internal Medicine Department of Ain- Shams University Hospital. Thyroid stimulating hormone (TSH), thyroid hormones including T3 and T4, antithyroglobulin antibodies (ATGAb), thyroid peroxidase antibodies (TPOAb), ESR, RF, ANA, LE cells and CRP were determined. Results. 46.6 percent of SLE patients showed thyroid dysfunction compared to 16.6% of RA (P<0.05). In SLE group, 20% had euthyroid sick syndrome, 16 % had hypothyroidism (10% subclinical and 6% overt), and 9% had hyperthyroidism (3% subclinical and 6% overt). However in RA, 13% had hypothyroidism (10% subclinical and 3% overt) and 3% had subclinical hyperthyroidism. TPOAb was found in 16% of SLE and 6% in RA patients. Also ATGAb was found in 6% of SLE and 30% in RA patients and 10% of controls, but the titers were higher in the patients. Conclusion. Thyroid dysfunction was common in patients with SCTD and they were associated with antithyroid antibodies.
Authors and Affiliations
Heba Sayed Assal| Internal Medicine Department, National Research Center, Cairo-Egypt, Ashraf Elsherbiny| Internal Medicine Department, National Research Center, Cairo-Egypt, Ahmed Alsayed| Internal Medicine Department, National Research Center, Cairo-Egypt, Mohamed Abdel Maaboud| Internal Medicine Department,Faculty of Medicine, Ainshams University, Cairo-Egypt, Hesham alShabrawi| Internal Medicine Department, Ahmed Maher Teaching Hospital, Cairo-Egypt, Enas Abdel Rasheed| Clinical and Chemical Pathology Department, National Research Center, Cairo-Egypt
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- EP ID EP8700
- DOI 10.3889/MJMS.1857-5773.2009.0059
- Views 380
- Downloads 21
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