Abstract

Background – Chronic Renal Failure(CRF)patients on dialysis have shown alteration in their thyroid status, however conflicting results do not allow to have conclusive identification of the impact. Aim – The study was to evaluate the thyroid hormone profile and gender influence in undialyzed CRF patients and to compare with that of healthy individuals. Method – The study group was consisted of 80 volunteers including 40 undialyzed CRF patients and 40 age matched healthy volunteers. Thyroid hormonal profile like Total Triiodothyronine (TT3), Total Thyroxine (TT4),FreeTriiodothyronine (FT3),Free Thyroxine (FT4) ,Thyroid Stimulating Hormone (TSH) and Renal function parameters like serum creatinine were estimated by standard automated methods and compared with healthy control groups. Results – The serum levels of TT4,TT3 and FT4 showed significant decreases and TSH increased significantly in undialyzed CRF patients compared to the healthy controls. Interestingly obvious differences were observed in between genders within the undialyzed CRF patients. Conclusion – On the basis of observation reported here, it can be summarized that renal insufficiency may lead to subclinical hypothyroidism in un dialyzed CRF patients. Nevertheless, the statistical tests used here did not find significant influences of gender in the current study

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