Thyroid function parameters, body mass index and serum lipid profile in subclinical hypothyroidism: a hospital-based study of effect of levothyroxine replacement therapy in Srinagar, Jammu and Kashmir
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: The Present study aimed to assess the effect of levothyroxine replacement therapy on serum lipid profile and thyroid function parameters of patients on subclinical hypothyroidism. We also aimed to correlate the lipid profile parameters with body mass index. Methods: Ninety patients of subclinical hypothyroidism treated with levothyroxine for three months were included in the study. Fifty three euthyroid subjects served as controls. Levels of serum TSH, total cholesterol were assayed before and after levothyroxine therapy in patients with subclinical hypothyroidism. Levels of serum TSH, total cholesterol, LDL-cholesterol, HDL-cholesterol, T3 and T4 in subclinical hypothyroidism patient’s post-levothyroxine therapy were compared with those of euthyroid controls, and correlated with body mass index. Results: The study demonstrated significant decrease in serum total cholesterol levels in subclinical hypothyroidism patients on levothyroxine treatment (P <0.001). Male hypothyroid subjects showed significantly lower serum triglycerides, post thyroxine therapy, when compared to euthyroid males (P <0.001). In females, hypothyroid subjects post-thyroxine treatment showed significant difference with euthyroid controls with respect to triglycerides and LDL-cholesterol (P<0.001). Male obese and normal weight hypothyroid subjects (post-thyroxine) differed significantly with respect to LDL-cholesterol, and total cholesterol (significantly higher levels in obese; P <0.001). The obese and overweight groups differed significantly (P<0.001) with respect to LDL-cholesterol. In female hypothyroid subjects post-thyroxine treatment, LDL-cholesterol and triglycerides were significantly higher (p<0.001) in overweight and obese when compared to normal weight females. Conclusions: Subjects with subclinical hypothyroidism showed significant improvement in dyslipidemia and thyroid hormones on treatment with L-thyroxine.
Authors and Affiliations
Rama Jailkhani, AR Shivashankara, Manjot Sahni, JB Honnamurthy
Keywords
Related Articles
- EP ID EP295929
- DOI 10.18231/2394-6377.2017.0022
- Views 62
- Downloads 0
Evaluation of microalbuminuria in non-diabetic and non-hypertensive patients with acute myocardial infarction
Introduction: Microalbuminuria is defined as the excretion of 30to 300mg of albumin per day in urine. It is frequently present and a known cardiovascular risk indicator in diabetic populations, in hypertensive and genera...
Assessment of Lipoprotein (a) and Lipid Profile Pattern in patients of Pre-Eclampsia
Introduction: Preeclampsia is a hypertensive disorder of pregnancy characterized by endothelial dysfunction. The present study was planned to assess and compare the levels of serum Lipoprotein (a) and lipid profile in pr...
Utilization of laboratory services and perspective of lab practices among clinicians: A cross sectional study
Introduction In recent years the care of patients has become increasingly dependent on the results of lab investigations Lab investigations have always been and will continue to be an integral part of clinical practice C...
Gender specific utility of lipid ratios and its correlation with systemic inflammation in acute myocardial infarction (AMI) patients with type 2 diabetes mellitus – A hospital based study
Objective To evaluate Gender specific alterations in the levels of serum lipid profile parameters Total Cholesterol TC Triglycerides TG Low density lipoprotein Cholesterol LDLC High density lipoprotein Cholesterol HDLC n...
Relationship between higher Serum ferritin levels, Insulin resistance marker and components of metabolic syndrome in Men and Women in west part of India
Background: There are no effective studies in west part of India on relationship between higher serum ferritin levels in impaired glucose individuals, type 2 diabetes mellitus patients are markers for insulin resistance...