THYROID HORMONE PROFILE IN PATIENTS WITH GASTROINTESTINAL MALIGNANCIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 18
Abstract
BACKGROUND Gastrointestinal malignancies is most frequently diagnosed life-threatening cancer in humans. Thyroid hormones play a critical role in growth and development of alimentary tract. Evidence has implicated components of thyroid hormone signaling in development and progression of various cancers of alimentary tract. There is ongoing effort geared towards developing next generation TR specific agonists and antagonists, such molecules may have applicability in gastrointestinal cancer prevention and treatment. MATERIALS AND METHODS Cases - 60 cases of GI malignancies were taken, 15 each of gastric, oesophageal, colorectal, pancreatic cancers. Controls- 60 age and sex matched controls. All patients were investigated for T3, T4, TSH and TPO antibodies. RESULTS Statistically low mean t3, t4 and high TSH in cases compared to controls and TPO antibody levels raised in cases. CONCLUSION In GI malignancy, thyroid dysfunction is seen. Low level of thyroid hormone is seen in cases, even though there is no overt hypothyroidism.
Authors and Affiliations
Vivek V, Lakshmanan P. P, Anilakumari V. P
Keywords
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