Thyroid Screening in Obstetric Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Background: Although gestational hyperthyroidism is uncommon (0.2%), Hypothyroidism occurs in 2.5% to 3% of women and is predictive of reduced neonatal and child neuropsychological development and maternal obstetric complications. Postpartum thyroid dysfunction occurs in 5-9% of women and is associated with anti thyroid peroxidase antibodies in 10% of women in early pregnancy. Therefore, screening of thyroid dysfunction in pregnancy should be considered. T4 and TSH measurements could be used to screen for hypothyroidism, which would require levothyroxine treatment. T4 supply is crucial for maturation of fetal nervous system. Methods: Study was done in 1000 pregnant women. Screening was done by estimating T3, T4, TSH. Results: Out of 1000 pregnant women, 30 were diagnosed as hypothyroidism. Among them 5 were diagnosed as overt hypothyroidism and 25 cases were sub clinical hypothyroidism. 18 cases were diagnosed as hyperthyroidism. Among them 2 were overt hyperthyroidism and 16 were sub clinical hyperthyroidism. These patients are followed up and hypothyroid patients were treated with levothyroxine, hyperthyroid patients were treated with Propylthiouracil. Conclusion: Potential and inadequately treated hypothyroid patients present with problems in pregnancy. While adequately treated, hypothyroid or hyperthyroid women get normal ongoing pregnancy. So to identify these potential or overt hypothyroid women, and risk based screening has been shown to miss at least 30% of cases. So universal thyroid screening with T3, T4, TSH must be done during prenatal, at first booking, and repeated at 8 weeks interval thereafter in pregnancy.
Authors and Affiliations
Dr. B. Srinivas Rao, Dr. E. Indira, Dr. R. Rama
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