Thyroid Status in Non-Pregnant & Pregnant Women

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Thyroid Status in Non-Pregnant & Pregnant Women

Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6

Abstract

Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound seen as a result of a normal physiologic state. Thyroid hormones have important role in embryogenesis and fetal development during pregnancy. Therefore, thyroid status is frequently assessed during pregnancy, both to evaluate suspected thyroid abnormalities, and to monitor the status of pre-existing thyroid disease. The aim and objective of the study was to compare thyroid function test in each trimester in normal pregnant women with non pregnant women. A case-control study containing two groups of women,75 normal pregnant women as cases selected from the first trimester (25 samples), the second trimester (25 samples), and the third (25 samples) trimester and 75 randomly selected non-pregnant healthy female controls. Thyroid function tests were carried out by measuring the serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT4, T4), and free and total triiodothyronine (FT3, T3) by commercially available radio-immunoassay kit. The statistical significance was evaluated by Student’s t-test. p value <0.05 was the level of statistically significance. In the third trimester, the mean TT4 increased significantly than the mean of non-pregnant women. The mean TT3 levels of pregnant women was increased in the second trimesters, and declined in the third trimester than the mean of non-pregnant women. In the third trimester, the mean FT4 significantly decreased than the mean for non-pregnant women. Mean FT3 values showed declining over the trimesters relative to the non-pregnant control group that were significant in second and third trimesters. In each trimester, the mean TSH levels of pregnant women were lower than the mean level of non-pregnant but were not statistically significant in second and third trimesters. The thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals in order to avoid mis-interpretation of thyroid function during pregnancy. Keywords: Pregnancy, Thyroid stimulating hormone (TSH), Free thyroxine (FT4), Total thyroxin (T4), Free triiodothyronine (FT3), Total triiodothyronine (T3).

Authors and Affiliations

Manjunatha S, Basavraja G N, Veena H C, Ramesh S Patil

Keywords

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EP ID EP378510
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