Thyroid Stimulating Hormone As A Possible Predictor Of Preeclampsia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Background- Thyroid disorders constitute one of the most common endocrine disorders in pregnancy.Thyroid undergoes profound modification in pregnancy but less study has been done on thyroid function changes in preeclampsia . Pregnancy is associated with increased total thyroxin (T4) and, in preeclampsia, biochemical hypothyroidism occurs (i.e. raised thyroid-stimulating hormone, TSH). Hypothyroidism has been listed as one of the causes of high blood pressure.Material and Methods-The present study was carried out on the pregnant women in their second and third trimesters attending outpatient department of obstetric and gynaecology from October2012 to September2014. 100 Preeclamptic women were included in the study group and 50 normotensive women were included in the control group. Both groups were screened for hypothyroidism and the data so collected entered into MS exel and data analysis done.Result- Incidence of hypothyroidism in normotensive pregnant women was 12% and the incidence of hypothyroidism in preeclamptic women was 42%. The mean (±SD) TSH of the study and control group was 2.407±0.171mIU/L and I.5±0.954mIU/L respectively. The mean (±SD) fT3 of the study group and control group were 1.422±0.621 pg/ml and 1.604±0.63 pg/ml respectively. The difference in the number of pregnant women of the two groups having high TSH titre was also significant. More number of preeclamptic women had increased serum TSH level at the time of diagnosis when compared with normotensive pregnant women.Conclusion- In the present study, serum TSH was significantly higher in preeclamptic women than in normotensive women and fT3 and fT4 were slightly lower in preeclamptic women. Since pregnancy is generally associated with hyperthyroxinemia, degree of hypothyroxinemia might reflect the severity of preeclampsia.
Authors and Affiliations
Dr Anita Kumari Murmu, Dr Akriti Prasad, Dr Amrita Sharan, Dr Surendra Baskey
Keywords
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- EP ID EP373666
- DOI 10.9790/0853-1704170109.
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