Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration
Journal Title: Journal of Animal Production Advances - Year 2013, Vol 3, Issue 4
Abstract
A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs were slaughtered 24, 48, 72 and 96 hours later of oral treatment withdrawn and post intramuscular treatment. The longer WDT was 2.95 days for the PO administration and 1.73 days for the IM administration; therefore, WDTs of 3 days and 2 days, respectively, could be assigned as a precautionary principle for public health, without a significant economic impact for the swine producer.
Authors and Affiliations
D. S. Pérez , A. L. Soraci , M. O. Tapia
Keywords
Related Articles
- EP ID EP156939
- DOI -
- Views 103
- Downloads 0
Perception of Smallholder Farmers on fodder Tree Utilization and Management for Livestock Production in the Mid-Hills of Nepal
A field survey was conducted in 2009 at Sundarbazar and Anppipal village development committees (VDC) of Lamjung and Gorkha districts to understand the indigenous fodder trees utilization and management practices in the...
Reproductive Biology of the Sea Cucumbers for Successful Breeding: a Review
Information for the successful breeding of the commercial sea cucumber involves getting data via academic studies or can be based on tentative information about spawning times in local areas of collecting. Determination...
Bone Development in Guinea Fowl Fed Diets Containing Three Cereal Grains as Sources of Energy up to 12 Weeks of Age
The effects of three cereal grains on bone development of guinea fowl up to 12 weeks of age were investigated. A total of 240 day old keets were randomly assigned to four treatment groups each having four replicates. The...
Studies on Process Standardization of Cow Milk Ujani Basundi
A study on the standardization of Ujani basundi was carried out by using cow milk. Milk was standardized to 4% fat and 8.5% SNF (Solids Not Fat). The attempts have been made to study the effect of different levels of sug...
Acclimation in Semen Traits and Reaction Time in Large White and Crossbred Boars Exposed to Direct Solar Heat Stress
The objectives of the study were to evaluate and compare acclimation in semen traits of Large White (LW) and Large White x local (LW x LC) F1 (crossbred) boars to high ambient temperatures during exposure to direct solar...