Tissue Microarray TechnologyA Brief Review
Journal Title: National Journal of Laboratory Medicine - Year 2018, Vol 7, Issue 1
Abstract
In this era of modern revolutionisation in the field of medical laboratory technology, everyone is aiming at taking the innovations from laboratory to bed side. One such technique that is most relevant to the pathologic community is Tissue Microarray (TMA) technology. This is becoming quite popular amongst all the members of this family, right from laboratory scientists to clinicians and residents to technologists. The reason for this technique to gain popularity is attributed to its cost effectiveness and time saving protocols. Though, every technique is accompanied by disadvantages, the benefits out number them. This technique is very versatile as many downstream molecular assays such as immunohistochemistry, cytogenetic studies, Fluorescent In situ-Hybridisation (FISH) etc., can be carried out on a single slide with multiple numbers of samples. It is a very practical approach that aids effectively to identify novel biomarkers in cancer diagnostics and therapeutics. It helps in assessing the molecular markers on a large scale very quickly. Also, the quality assurance protocols in pathological laboratory has exploited TMA to a great extent. However, the application of TMA technology is beyond oncology. This review shall focus on the different aspects of this technology such as construction of TMA, instrumentation, types, advantages and disadvantages and utilisation of the technique in various disease conditions.
Authors and Affiliations
Ramya S Vokuda, Surendra Kumar Verma, Bheemanathi Hanuman Srinivas
Keywords
Related Articles
- EP ID EP528908
- DOI 10.7860/NJLM/2018/31639:2271
- Views 144
- Downloads 0
Screening of Prostate Cancer by Prostate Specific Antigen and its Prevalence in Jammu Region
Introduction: Prostate cancer is most commonly diagnosed non-cutaneous cancer in men. Prostate specific antigen is the biomarker used for screening of prostate cancer and prostate related problems. Not only the genetic f...
Bacteriological Profile and Antibiogram of Urinary Tract Infections at a Tertiary Care Hospital
Introduction: Urinary tract infections (UTI) are amongst the most common cause of bacterial infections in humans. It encompasses a wide array of infections, accounting for a vast number of community as well as hospital a...
Multigravidity a Major Risk Factor of Anaemia in Pregnancy and its Comparison in Primigravida Women in Raichur
Introduction: Among etiological factors, multiparity remains inconclusive with various conflicting studies. Considering that multiparity is a common norm in the reproductive life of women in developing countries it is im...
Pap Smear Evaluation through Opportunistic Screening Programme in Tertiary Care Hospitals and Rural Mangalore
Introduction: Pap smear cytology enables the cytopathologist to detect and evaluate the degree of cellular alterations present in uterine cervical lesions. Cytopathological analysis of these smears has stood out amongst...
Hemophagocytic Lymphohistiocytosis in Adults and Adolescents - Experience from a Tertiary Care Centre in South India
Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of immune dysregulation. It is characterized by hypercytokinemia and macrophage activation resulting in fever, cytopenia, splenomegaly and hyperfe...