TNF-α Inhibitor Treatment for Crohn’s Disease: Comparative Review of Post Therapy Malignancy between Infliximab and Adalimumab
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 5, Issue 4
Abstract
The association between chronic inflammatory disease and cancer has been well established through years of research. In corollary, progressive resistance to chimeric monoclonal antibodies has been reported in literature. The purpose of this investigation was to establish the overall trend of the chimeric monoclonal antibody (Infliximab) failure compared with human monoclonal antibody (Adalimumab). It was opined that this failure may result in subclinical yet cancer-inducing inflammation that could be measurable in patient populations undergoing the therapy by examining cancer prevalence. An overall trend of increased incidence of new malignancy in patient populations on Infliximab compared with Adalimumab was confirmed from the literature reviewed. There was also a significant trend of developing Gastrointestinal (GI) related cancer in patients on Infliximab, which corresponds with the majority of the progression process in Crohn’s disease. It was opined that future observations in clinical practice will lead to the phasing out of Infliximab as a front-line monoclonal antibody in the treatment of Crohn’s disease in favor of less immunogenic monoclonal antibodies. In conclusion an increased incidence of both general and GI malignancies has been widely reported in patient populations undergoing Infliximab therapy than with Adalimumab.
Authors and Affiliations
Danil Hammoudi, Adekunle Sanyaolu, Nirav Nagarsheth, Jason Kimbel, Amos Abioye
Keywords
Related Articles
- EP ID EP344740
- DOI 10.9734/BJPR/2015/12381
- Views 83
- Downloads 0
Histomorphological Evaluation of Reproductive Organs Following Piper betel (Linn.) Leaf Stalk Extract Administration in Male Albino Rats
Aim: To evaluate the histological effects of Piper betel leaf stalk extract on reproductive organs and the liver in male rats Study Design: Aqueous P. betel leaf stalk extract was administered to rats at the dose of 50...
Square Wave Voltammetric Determination of Ropinirole HCl in Bulk, Dosage Forms and Biological Samples on Carbon Paste Electrode
Aim: Voltammetric determination for of Ropinirole HCl. Study: We will study the behaviour of Ropinirole HCl on the carbon paste electrode. So several factors such as pH, type of pasting oil, pulse amplitude and scan rat...
Signal Detection and Clarification of Peripheral Neuropathy and Guillain-Barré Syndrome Associated with Exposure to Systemic Fluoroquinolones
Aims: Peripheral neuropathy (PN) is an identified risk of systemic antibacterial therapy with fluoroquinolones. The risk and its severity, including the development of Guillain-Barré syndrome (GBS) between individual age...
Development, Characterization and Ex vivo Evaluation of Various Liposome-encapsulated Aceclofenac Formulations
Aim: Formulation of aceclofenac (ACE) into liposomal gel, improving its skin permeation and potentiate its local anti-inflammatory effect. Methodology: ACE liposomes were fabricated by lipid film hydration technique. Th...
Quantitative Structure-activity Relationships (QSAR) and Docking Studies on Pyrimidine Derivatives for Antitubercular Activity against M. tuberculosis H37Rv
Aim: QSAR techniques and docking increase the probability of success and reduce time and coast in drug discovery process. The study presents QSAR investigation on 20 pyrimidine derivatives for antitubercular activity aga...